Chemophobia and taboo in drug prohibition

Chemophobia is an irrational fear of chemicals and chemistry. Many examples exist. Some individuals believe certain synthetic chemicals are toxins whereas “natural” or derived substances are safe, even though the two substances are identical in every other respect. Similar reactions occur with cannabis. Recreational marijuana is condemned while medical marijuana is acceptable, even though the marijuana flowers used recreationally or medicinally can originate from the same plant.

Chemophobics believe toxicity is determined by the substance alone. In point of fact the harm comes from excessive exposures or dosages. Levels of toxicity are measured by laboratory testing to determine toxicity for animals of a given body weight. A problem for prohibitionists who want THC and psilocybin use to remain criminalized, and its users stigmatized, is that no toxic levels can be determined for either of the two chemical compounds. Prohibitionists are left with few other options than to declare the two substances to be taboo.

Sigmund Freud, the father of psychoanalysis, in his 1913 book Totem and Taboo, analyzed social phenomena and behavior which will likely be recognized by those caught up in the anguish and confusion emerging from the modern drug war:

The taboo restrictions are different from religious or moral prohibitions. They are not traced to a commandment of a god but really they themselves impose their own prohibitions; they are differentiated from moral prohibition by failing to be included in a system which declares abstinences in general to be necessary and gives reason for this necessity. The taboo prohibitions lack all justification and are of unknown origin. Though incomprehensible to us they are taken as a matter of course by those who are under their dominance. […]

Wherever the taboo was related to ideas of gods and demons, automatic punishment was expected from the poser of the godhead. In other cases, probably because of a further development of the idea, society took over the punishment of the offender whose action has endangered his companions. […]

The violation of a taboo makes the offender himself taboo … certain dangers resulting from the violation of a taboo may be exercised through acts of penance and ceremonies of purification. […]

We may say … we deal with a series of restrictions which these primitive people impose upon themselves; this and that is forbidden without any apparent reason; nor does it occur to them to question this matter, for they subject themselves to these restrictions as a matter of course and are convinced that any transgression will be punished automatically in the most severe manner. […]

The most peculiar part of it is that anyone who has violated such a prohibition assumes the nature of the forbidden object as if he had absorbed the whole dangerous charge. […]

Both this word and the system corresponding to it express a fragment of psychic life which really is not comprehensible to us. And indeed, it would seem that no understanding of it could be possible without entering into the study of the belief in spirits and demons which is so characteristic of these low grades of culture. […]

Taboos are a big business in the United States. Aside from drug enforcement, drug rehabilitation centers fulfill the role of providing acts of penance and ceremonies of purification for those caught using taboo substances. The drug rehab industry receives multi-billions of dollars in federal funding each year through Medicare, Medicaid, SAMSHA, and other HHS programs.

Until a cure for addictions can be found, drug rehabilitation programs offer fairly effective addiction treatments when combined with therapeutically prescribed drugs. Unfortunately, more than 95-percent of people needing drug rehabilitation in 2023 did not receive it.

Despite the promising results offered by psychedelic compounds for addiction treatment, lobbying costs for legalizing psychedelic use and therapies comes from psychedelic startups and not Big Pharma. Pharmaceutical companies are certain to lose revenue from drugs they currently market if any of their products are made obsolete by easy access to non-patentable psychedelics and THC.

Any individual who stands accused of assuming or absorbing the forbidden nature of a drug — according to taboos that equate the drug with a drug’s consumer — is a victim of an insane process leading to schemes that demonize and brand people. Prejudices and stereotypes make drug wars possible. Authoritarian governments promoting punishments of those whose drug use offends a particular culture’s god, guru, or religious beliefs, are virtually guaranteed to foment wars and inquisitions. The bloodiest European battle ever fought was the Thirty Years War (1618-1648). Eight-million people were killed with what began as domestic clashes between established Catholics and dissident Protestants.

Despite all the warring parties, progress in combating drug taboos and drug wars is still achievable by employing education that reduces chemophobia through increasing public awareness of basic chemistry and other sciences. As with all social changes there are obstacles to overcome.

People avoid studying science or chemistry because it is abstract and therefore difficult. The topic requires studying physics and complicated math as well as chemicals and their molecular interactions. Science demands different ways of thinking from people who may have been continuously persuaded by ethnocentric cultures to never think for themselves. Science studies can take up much of a person’s time. Some students fear focusing on science because the workload could result in lowering their grade point average. Time spent on science studies can also force students to cut back on their social activities.

Another problem for American science education is that various religious groups deliberately steer their members away from science altogether. Books about dinosaurs are sometimes prohibited from appearing on the library bookshelves of publicly funded primary schools. Science instruction in some school districts is limited to middle and high school students. Even then it’s only offered in the form of elective courses. An ignorance of science is preferred to that of initiating quality science teaching early on in public primary schools where it can prove most interesting and mentally stimulating to younger audiences.

Among many other anti-medicine cults, sects and religions that reject modern medicine, the Christian Science religion doesn’t believe in the germ theory of disease or the use of drugs to treat disease. It demeans science knowledge among its members while promoting a theology of fatalism that says deaths from illnesses are predetermined and inevitable despite the existence of medicines that can treat or cure afflictions. The drug taboos pertain to Christian Science children as well as adults. Jehovah’s Witnesses believe blood transfusions are taboo. In their world view a blood transfer from one person to another is a form of cannibalism, so they reject common surgeries requiring transfusions that can save their own lives or the lives of their family members. Mormonism treats tea and coffee as taboo despite growing scientific evidence showing that moderate levels of caffeine in tea or coffee can help reduce the onset of dementia. Then there are the anti-vaxxers.

Reversing the annoying trend of America’s paranoid chemophobia would profoundly improve public health. People who seek to understand their own brain chemistry and that of others typically make better choices about drug use and vaccinations along with nearly everything else health related. Rather than saying no to drugs, they just say know to drugs, resulting in longer, happier, and better lives.

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12 Responses to Chemophobia and taboo in drug prohibition

  1. Servetus says:

    Republican Iowa gubernatorial candidate Adam Steen claims abortion drugs such as mifepristone are contaminating the local water supply:

    About an hour into the Republican gubernatorial debate in Iowa earlier this year, Adam Steen, who is one of the leading candidates in the primary, made an eye-popping claim.

    “We need to decimate the chemical abortions,” Steen said. “You talk about water quality, what’s happening in our water because of that, those chemical abortions that are coming through there.” […]

    The comment received relatively little notice apart from a few mentions on social media. However, Steen’s claim was notable both as an indication of how far to the right the GOP gubernatorial hopefuls are running in a state that already bans most abortions after six weeks and because it is part of a national push from anti-abortion groups to make speculative and far fetched environmental concerns a core part of their messaging. The effort to frame abortion medication as a threat to the water supply is one such claim, and lacks any concrete scientific basis. […]

    After declaring “life begins at conception” and calling that point “the most important issue of this entire gubernatorial race,” Steen launched into his remarks connecting water safety, which is an especially pertinent issue in Iowa, with the right-wing cause of limiting access to abortion. […]

    A spokesperson said Steen was “referencing” a white paper titled “Abortion In Our Water” that was produced by the group Liberty Counsel Action last year. The report claims “our waterways are being contaminated by chemical abortion drugs and human remains as American women — left alone at home to endure the agonizing process of expelling their pregnancy — are often instructed by abortion providers to dispose of their aborted child’s remains down the toilet.”

    Liberty Counsel Action shares some leadership with Liberty Counsel, which has been labeled a hate group by the Southern Poverty Law Center. The group is a legal organization closely affiliated with the evangelical Liberty University. […]

    Water quality is a serious issue in Iowa, said Prof. David Cwiertny, an engineer and wastewater expert who is the director of the University of Iowa’s Center for Health Effects of Environmental Contamination. However, unlike Steen, he did not attribute the problem to abortion.

    “Our biggest issue is nitrate levels — which is a regulated contaminant — are high, and many communities are having to seek out other sources that are not contaminated by nitrate,” Cwiertny explained.

    Iowa is a center for farming and meat processing. Agricultural runoff contains nitrates from manure and fertilizer. Nitrates have been linked to high rates of cancer in the state. […]

    While Cwiertny said the water quality discussion should be broadened to encompass other chemicals like pesticides and fungicides as well as some widely used medicines, he does not see mifepristone as a high priority area of concern. […]

    Cwiertny suggested Liberty Counsel’s concerns about human remains from terminated pregnancies in the water supply were overblown.

    Cwiertny noted that mifepristone is only used by “a subset of the population that’s a subset of the population.” As such, he questioned whether it would even be identifiable in water systems.

    “In that report, they talk about 30 to 40 tons of hazardous medical waste — including human remains — being flushed into the water systems. 30 to 40 tons. I don’t know if that’s on an annual basis, I’m assuming it is, because they’re talking about the number of chemical abortions per year,” said Cwiertny. “For perspective, publicly owned treatment works generate over 13.8 million tons of dry weight sludge. So it’s a matter of scale. If we’re producing, you know, 14 million tons of solids from human waste after it’s been dewatered, focusing on 30 to 40 is — that’s, like, not even a drop in the bucket.” […]

    In general, while Cwiertny said experts should be addressing issues of more widely used chemicals in the water supply, he also noted that modern treatment systems are robust. They can accommodate medicines and human waste from medical procedures.

    “We put human waste down sewers. That is just what they’re there for, and they are designed to handle relatively large masses of human waste flushed down toilets daily,” Cwiertny said. “The system is designed that way. And we do have advanced treatment these days, and more and more water systems are turning to them to produce water coming out of wastewater that is as pure as you can find.” […]

    Talking Points Memo: Pseudoscientific Push to Frame Abortion as a ‘Water Quality’ Issue Rears Its Head in Iowa

    Author: Hunter Walker

    • Shane from Slidell says:

      If the likes of Kat Cammack have taught me anything, you can get away with anything as long as you can hypocritically blame someone else for your problems. The anti-abortion movement is a lie. (Just look into its history with the Social Purity Movement, Horatio Storer, the American Medical Association, and Anthony Comstock.)

  2. Servetus says:

    Reduce liver fat and improve metabolic health with CBD and CBG:

    Scientists have identified two non intoxicating compounds from cannabis that may help reduce liver fat while improving metabolic health. The compounds, CBD and CBG, appear to support the liver in two important ways. They increase the organ’s ability to store backup energy and restore the activity of cellular systems that break down harmful waste. Together, these effects could offer a new plant based strategy for treating the most common chronic liver disorder worldwide.

    [The] study suggests that Cannabidiol (CBD) and Cannabigerol (CBG), which do not cause a high, may improve liver health by altering how liver cells handle energy and remove unwanted material. […]

    Using advanced scientific tools, the researchers discovered that CBD and CBG do more than simply reduce fat accumulation. The compounds appear to improve the internal functioning of liver cells through a process called “metabolic remodeling.”

    One key discovery involved the liver’s energy reserves. The compounds increased levels of phosphocreatine, a molecule that acts like an emergency energy supply. This backup energy source helps liver cells maintain normal function when exposed to metabolic stress such as a high fat diet. Scientists note that the liver does not usually rely heavily on this system, making the finding particularly notable. […]

    The study also showed that CBD and CBG reactivate cathepsins. These enzymes operate inside lysosomes, which serve as recycling centers within the cell. Their role is to break down unwanted materials so they can be removed.

    When cathepsin activity is restored, liver cells become better equipped to process and eliminate harmful fats and waste. The researchers observed major reductions in damaging lipid molecules including triglycerides and ceramides. Ceramides are especially harmful because they are linked to insulin resistance and inflammation in the liver. […]

    Although both compounds produced beneficial effects, the study found that they influence metabolic health in slightly different ways. CBD and CBG both helped stabilize blood sugar levels and improved how the body processes glucose.

    However, CBG produced stronger improvements in several metabolic markers. It significantly reduced body fat mass and increased insulin sensitivity more than CBD. The compound also showed a stronger ability to lower total cholesterol and levels of “bad” LDL cholesterol.

    “Our findings identify a new mechanism by which CBD and CBG enhance hepatic energy and lysosomal function,” says Prof. Joseph Tam. “This dual metabolic remodeling contributes to improved liver lipid handling and highlights these compounds as promising therapeutic agents for MASLD.” […]

    Science Daily: Cannabis compounds CBD and CBG may help reverse fatty liver disease, study finds, CBD and CBG may help the liver burn fat, restore metabolism, and fight fatty liver disease

    British Journal of Pharmacology: Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

    Authors: Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam.

  3. Servetus says:

    Robert F Kennedy Jr says he has ADHD and that the opioids he used as a teenager suppressed his symptoms.

    Kennedy, whose past addiction to heroin is widely known, said he believes he started taking the drug to self-medicate. “Back then, they didn’t give you Adderall and stuff. [Heroin] was my Adderall. I could sit, I could write, I could read, I could comprehend. And I was functional on it.”

    He said when he started taking the opioid, he “went from the worst kid in my class to the first, second, or third academically in my class for the rest of my career, because it calmed me down. It made me so that I could sit still, which I could not sit still, my brain was in turmoil all the time. I couldn’t concentrate. I couldn’t sit still and read.”

    His addiction caught up with him in 1983 when he was arrested for heroin possession, but he said that enabled him to get into rehab and clean up his act. […]

    • Shane from Slidell says:

      I’ve always found Robert Jr. to be a shifty, hypocritical, detestable character. Not at all different from his racist, anti-Semitic Father and corrupt uncles. (Or for that matter, Anthony Fauci.)

  4. Servetus says:

    Researchers at KAIST and UCSD discover and describe the brain’s addiction circuit:

    11-Mar-2026 – Drug addiction carries an extremely high risk of relapse, as cravings can be reignited by minor stimuli even long after one has stopped using. Previously, this phenomenon was attributed to a decline in the function of the prefrontal cortex (PFC), which regulates impulses. However, a joint international research team has recently revealed that the cause of addiction relapse is not a simple decline in brain function, but rather an imbalance in specific neural circuits.

    KAIST announced on March 9th that a research team led by Prof. Se-Bum Paik from the Department of Brain and Cognitive Sciences and Prof. Byung Kook Lim from the University of California, San Diego (UCSD) has identified the core principle by which specific inhibitory neurons in the prefrontal cortex regulate cocaine-seeking behavior. […]

    The research team confirmed that artificially suppressing PV cell activity significantly reduced cocaine-seeking behavior in mice. Conversely, activating these cells caused the drug-seeking behavior to persist even after the extinction process. This effect was specifically observed in drug-addiction behavior and did not appear with general rewards like sugar water. Furthermore, this phenomenon was not observed in somatostatin (SOM) cells—another type of inhibitory neuron—indicating that PV cells selectively regulate drug addiction behavior.

    The team also identified the specific brain circuit through which these PV cells operate. Signals originating from the prefrontal cortex are transmitted to the reward circuit of the Ventral Tegmental Area (VTA), a key brain region related to reward. This pathway emerged as the central channel for regulating addiction behavior, determining whether or not to seek the drug again. In this process, PV neurons act as a “regulatory switch,” controlling the flow of signals to influence dopamine signaling and deciding whether to maintain or suppress addictive behavior. […]

    In short, the study revealed that addiction relapse is not due to an overall functional decline of the prefrontal cortex, but is determined by whether PV neurons regulate the neural pathway connecting the PFC to the reward circuit.

    Prof. Se-Bum Paik stated, “This research shows that drug addiction is a circuit-level problem arising from a collapse in the regulatory balance of specific neurons and downstream neural circuits. The discovery that parvalbumin (PV) cells act as a ‘gate’ for addictive behavior will provide a crucial lead for developing precision-targeted treatment strategies in the future.” […]

    AAAS Public Science News Release: Secret to drug addiction relapse found: brain’s addiction circuit identified

    Neuron: Distinct interneuronal dynamics selectively gate target-specific cortical projections in drug seeking

    Authors: Minju Jeong, Seungdae Baek, Qingdi Wang, Li Yao1, Eun Ji Lee, Arturo Marroquin Rivera, Joann Jocelynn Lee, Hyeonseok Jang, Dhananjay Bambah-Mukku, Christine Hyun-Seung Mun, Tyler Boesen, Sumit Nanda, Cheol Ryong, Hong-wei Dong, Benoit Labonté, Se-Bum Paik, Byung Kook Lim.

  5. Servetus says:

    An NIDA funded study concludes that legalizing recreational cannabis reduces the size of the illegal cannabis market:

    10-Mar-2026 — Adopting recreational cannabis laws, beyond only medical cannabis laws, may help reduce the size of the illegal cannabis market in U.S. states, reports a new study by researchers at Columbia University Mailman School of Public Health. The study is among the first to comprehensively examine the dynamics of the illegal cannabis market using law enforcement seizure data. […]

    As of 2025, 40 U.S. states and Washington, DC have legalized medical cannabis, while 24 states and DC have legalized recreational cannabis, though cannabis remains a Schedule I substance under federal law.

    Using data from the High Intensity Drug Trafficking Areas Program (HIDTA), the team analyzed cannabis seizures made by participating law enforcement agencies in all 50 states and Washington, DC between 2010 and 2023. This is the first study to use HIDTA data to examine the effects of cannabis legalization on cannabis seizures.

    The data included 286,844 cannabis seizures across 686 state-year observations. Researchers linked these data with cannabis policy information from the RAND-USC Opioid Policy Tools and Information Center.

    Results showed that states adopting recreational cannabis laws in addition to medical cannabis laws experienced a 45 percent relative reduction in average cannabis seizure counts, compared with states that had only medical cannabis laws. The decline appeared both immediately after recreational cannabis law adoption and one year later, even after controlling for state demographic and law enforcement factors and time trends. […]

    “Another likely explanation is changes in law enforcement priorities. In jurisdictions where cannabis is legal, agencies may devote fewer resources to cannabis enforcement and instead focus on other drugs, such as illicitly manufactured fentanyl.”

    Illegal cannabis markets have not disappeared entirely in states with recreational legalization, Fitzgerald notes, but the findings suggest that regulated markets may be displacing part of the illegal supply. […]

    “The decrease in seizures may reflect a reduction in illegal cannabis supply, as consumers shift toward regulated markets and some illegal suppliers exit the market […]

    Overall, these results suggest that the adoption of recreational cannabis laws, beyond the adoption of only medical cannabis laws, may help to reduce the size of the illegal cannabis market in those states.” […]

    Columbia Mailman School of Public Health: Recreational cannabis laws may displace illegal cannabis markets — Legal markets may be reducing illegal cannabis activity while also shifting enforcement priorities

    International Journal of Drug Policy: Cannabis legalization and law enforcement drug seizures: a state-level analysis of cannabis policy effects on cannabis seizures in the United States, 2010–2023

    Authors: Nicole D. Fitzgerald, Joseph J. Palamar, Kechna Cadet, Esther Rowan, Emilie Bruzelius, Silvia S. Martins.

  6. Servetus says:

    Sen. Josh Hawley (R-MO) wants to ban the distribution and criminalize the use of mifepristone, a medication used in most abortions in the U.S.

    03-12-2026 — Anti-abortion groups have been frustrated that women living in states that banned abortion after the Supreme Court overturned Roe v. Wade have been able to access abortion medication by mail. They have been urging the Trump administration to withdraw a more than 20-year-old FDA approval for the drug’s use. Anti-abortion activists were outraged when in October 2025 the FDA approved a second generic version of the drug. Under pressure, HHS Secretary Robert Kennedy, Jr., announced a review of the drug’s safety. […]

    When Kennedy announced a safety review of the long-approved medication, which has a long safety record, the libertarian Cato Institute criticized the move, saying “Reopening a safety review for this drug appears to be driven by political rather than scientific reasons. This is not about the procedure itself but about the principle that safe, approved drugs should not be subject to political interference.”

    Hawley’s claim that the medication is “inherently dangerous” is based in part on a study published last year by the religious-right Ethics in Public Policy Center, though that study’s design and conclusions have been widely criticized. “It’s more like an anti-abortion press release with a chart to make it seem credible,” wrote one abortion-rights advocate.

    In January, the Journal of the American Medical Association published a review of the FDA’s decision-making regarding mifepristone, which concluded that “FDA oversight of mifepristone, developed during key moments from 2011 to 2023, has been shaped by scientific evidence and a cautious regulatory approach led by scientists at the agency.” […]

    At Hawley’s press conference, a questioner asked what he would say to Missouri voters who passed a constitutional amendment in 2024 protecting the right to abortion. Hawley noted that an effort to repeal that amendment will be on the ballot this fall and that he will be “out there making the case” for it. […]

    Right Wing Watch: Religious Right Cheers Josh Hawley Bill to Criminalize Abortion Medication

    Author: Peter Montgomery

    • Shane from Slidell says:

      Hawley and RFK Jr. both belong in jail and the chances of that happening are near zero. I’m glad that the Cato Institute called both of those pieces-of-shit out.

  7. Servetus says:

    Prevalence of drink spiking in the United Kingdom is surveyed:

    19-Mar-2026 — Since 2021, forensic science academics at ARU have partnered with the UK’s leading alcohol charity Drinkaware to track the prevalence of drink spiking through national surveys, undertaken by YouGov.

    The most recent survey, carried out in summer 2025 and involving 7,256 UK adults, found that approximately 2% of adults reported being a victim of drink spiking in the previous 12 months. When extrapolated across the UK population, this equates to nearly one million people.

    However, fewer than one in four (23%) of those who experienced drink spiking contacted the police. The most common reasons given for not reporting were not believing action would be taken by the police (39%) and not clearly remembering what had happened (38%).

    Women were more likely to experience spiking, accounting for 58% of cases. The most frequently reported locations were bars (41%), social events (26%) and nightclubs (25%), with the highest number of incidents reported by adults aged 25-34.

    Drink spiking involves adding a substance to someone’s drink without their knowledge. Substances may include illegal or pharmaceutical drugs, or alcohol, and incidents are most commonly associated with sexual assault, physical assault, theft and “pranks”. Giving someone stronger alcohol than they asked for, for example a double shot rather than a single, would also be classed as drink spiking.

    As well as investigating the scale of drinking spiking in the UK, the ARU Spiking Research Team carry out extensive research into the types of samples that can be tested following suspected spiking and the detection kits and protective products that are marketed to the public. […]

    Drink spiking has increased in the public’s consciousness in recent years, but our latest findings show that far too many cases still go unreported. With more than three quarters of victims not coming forward, it’s vital that we raise awareness about the importance of contacting the police and seeking support.

    At the same time, there remain significant challenges in identifying the different substances used in spiking. This talk will share our latest research into analysing drink residues, as well as our evaluations of drink testing kits and other anti-spiking products that are being sold to the public. […]

    AAAS Public Science News Release: Survey suggests one million UK adults had drink spiked in previous year — Latest UK drink spiking data to be presented during the Cambridge Festival

  8. Servetus says:

    Genetic risk tied to neural impulse control in the brain’s wiring affects addiction outcomes for drug users:

    20-Mar-2026 — Most of the genetic risk for developing a substance use disorder comes from genes that broadly affect how our brains process rewards, regulate impulses and weigh consequences – not from genes that specifically influence substance use disorder or any single drug.

    Researchers … analyzed genetic data from previously published genome-wide association studies totaling more than 2.2 million individuals to understand how genes shape vulnerability to alcohol, tobacco, cannabis and opioid use disorders.

    …members of the team found genetic risk operates along two main pathways:

    A broad “behavioral disinhibition” or externalizing pathway, which involves brain systems for reward processing, self-control and risk-taking. Externalizing refers to a heritable pattern of behaviors characterized by difficulty regulating impulses and actions such as impulsivity, attention-deficit/hyperactivity disorder (ADHD), conduct problems and risk-taking behaviors. This pathway cuts across many forms of addiction and related behavioral outcomes.

    Substance-specific pathways that are more narrowly tied to particular drugs (for example, genes involved in alcohol metabolism or nicotine receptors).

    Most of the genetic predisposition to substance use disorders isn’t about how bodies respond to drugs; it’s about how brains are wired … Specifically, risk is mostly related to genes that broadly impact how our brains process rewards and regulate behavior.

    Using advanced genomic methods, the researchers analyzed four substance use disorders –alcohol, tobacco, cannabis and opioids – together with related externalizing traits such as ADHD, risk-taking and initiation of substance use. This approach allowed them to identify hundreds of genetic variants associated with a broad externalizing liability as well as genes that were more specific to particular substances.

    The researchers found that modeling addiction together with these other traits greatly increased their ability to detect genetic effects without sacrificing the means to see substance-specific signals. Many of the genes linked to the broad liability were involved in brain signaling, reward processing and neural plasticity, while substance-specific genes mapped onto pathways such as alcohol metabolism or nicotinic acetylcholine receptors implicated in tobacco use. Traditionally, gene-finding efforts have focused on one disorder at a time … But substance use disorders almost never occur in isolation, and decades of twin and family studies have shown that they share a lot of their genetic roots with each other and with other externalizing conditions. By modeling that shared genetic architecture directly, we were able to discover more about both the broad and specific biological pathways that contribute to addiction.” […]

    In addition to mapping genetic risk pathways, the researchers conducted network and drug-target analyses that pointed to potential biological systems and medications that could be leveraged or repurposed for treatment. Many of the genes identified for the broad externalizing pathway overlapped with those implicated in other psychiatric and substance-related disorders, underscoring the shared biology across conditions. […]

    AAAS Public Science News Release: Genes tied to impulse control play a major role in addiction risk — An analysis of 2.2 million people reveals both shared and substance-specific genetic pathways for addiction risk, showing that vulnerability is rooted more in brain wiring than in any single substance

    Nature Mental Health: Multivariate genetic analyses of 2.2 million individuals reveal broad and substance-specific pathways of addiction risk

    Authors: Holly E. Poore, Chris Chatzinakos, Brittany Leger, Jean Gonzalez, Travis T. Mallard, Fazil Aliev, Alexander Hatoum, Irwin D. Waldman, Sandra Sanchez-Roige, Abraham A. Palmer, K. Paige Harden, Danielle M. Dick & Peter B. Barr.

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