MKUltra resurfaces as a new HBO series

CIA mind control experiments that exposed willing and more often unwilling people to mind-altering chemicals are the focus of an HBO series now in early production by David Chase. Chase is best known as the creator of the Emmy-winning mob drama The Sopranos. His latest drama series is based on John Lisle’s new book Project Mind Control: Sidney Gottlieb, the CIA, and the Tragedy of MKUltra.

John Lisle’s book goes into greater detail than previous MKUltra exposés. The reader gets to know the arch-chemist Sidney Gottlieb (aka The Black Sorcerer), who headed MKUltra while working at Langley, Virginia. On January 30, 1973, Gottlieb burned all his own files related to the secret drug dosing program. He was driven out of the CIA during the Nixon Watergate scandal. Gottlieb’s testimony before the Church and Pike Committees survived, and it is this testimony, along with seven displaced boxes of rediscovered MKUltra files, that is vividly revealed by Lisle.

One of the major mysteries surrounding MKUltra involves the circumstances of the death of CIA operative Frank Olson. Many have speculated that Olson was tossed out of a 13th-story hotel window by fellow CIA colleagues who feared he would panic and reveal details of the LSD experiments and MKUltra to the public. The fall was recounted by the Statler Hotel’s doorman, who yelled:

“We got a jumper, we got a jumper!” He later described Olson’s fall as “like the guy was diving, his hands out in front of him, but then his body twisted and he was coming down feet first, his arms grabbing at the air above him.” (p. 49)

Olson wasn’t the only fatality involving MKUltra. Gottlieb was a real-life super spy who could outshine any James Bond villain with scores of super-deadly brainwashing tricks all commissioned in the name of national security. He attempted to use psychedelic drugs to create an American-controlled Manchurian Candidate before the Communists could create one of their own. One witness to the Gottlieb family’s very private lifestyle was a young family friend of Peter Gottlieb named Elizabeth:

One day that summer, we were out at the house swimming. The parents had gone to the store to buy food for dinner, and Peter goes, kind of conspiratorially, “Come here. I want to show you something.” He takes me into his father’s den, his library, and says, “Turn around.” He did something—he didn’t want me to see what he did—and the wall of books opened up. Behind it was all this stuff. Weapons—I couldn’t tell which kind, but guns. There was other stuff back there. It was like a secret compartment. I couldn’t tell which kind, but guns. There was other stuff back there. It was like a secret compartment. I asked him, “What is that for?” He closed it back up quickly and said, “You know, my father has a price on his head.” I said, “Why, is he a criminal?” He said, “No, he works for the CIA.” Then he said, “You know, my dad has killed people. He made toothpaste to kill someone.” Later on he told me, “Don’t tell anyone that you were in there, and don’t ever tell anyone you know that my father kills people.” (p. 154).

If the Sopranos episodes are any indication of what to expect with the MKUltra production, David Chase’s new series should be just as outstanding and win just as many awards while providing a fascinating glimpse inside the CIA’s covert drug wars.

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2 Responses to MKUltra resurfaces as a new HBO series

  1. Servetus says:

    CBD for elderly dogs is proving effective in reducing canine aggression due to old-age anxiety and irritabilities (fight or flight) and in dealing with other health related problems:

    27 November 2025 — CBD is already used by many people for issues such as chronic pain, nausea, and inflammation. A new analysis suggests that dogs might also experience some of these benefits. Researchers in the US examined information from the Dog Aging Project to better understand the characteristics, health patterns, and behavior of dogs that received CBD or hemp supplements. […]

    “Behaviorally, dogs given CBD products for multiple years are initially more aggressive compared to dogs not receiving those products, but their aggression becomes less intense over time,” said senior author Dr. Maxwell Leung, an assistant professor and the director of Cannabis Analytics, Safety and Health Initiative at Arizona State University.

    “This long-term behavioral change highlights the potential of CBD as a therapy for canine behavioral issues,” added co-author Dr. Julia Albright, an associate professor at the College of Veterinary Medicine at the University of Tennessee. […]

    This research represents the most extensive effort so far to investigate CBD use among pet dogs in the US. The team relied on the Dog Aging Project, a long-term community science initiative in which owners provide yearly updates on their pets’ diet, lifestyle, health, and living conditions. A total of 47,355 dogs were included, with data collected through annual surveys between 2019 and 2023.

    Owners detailed how often their dogs consumed CBD or hemp products. Frequent users received a supplement every day, while infrequent users were given supplements less often than once a day. Owners could also indicate that their dogs had never been given CBD. […]

    Several health issues were linked to higher CBD use. The strongest association was seen in dogs with dementia (18.2%), followed by those with osteoarthritis joint problems (12.5%) and those diagnosed with cancer (10%).

    Dogs living in states where human medical cannabis is legal were also more likely to receive CBD. This may reflect how owners’ attitudes toward cannabis influence their decisions for their pets. Male dogs were given CBD more often, with a 9% higher likelihood than female dogs. However, activity levels did not differ significantly between dogs that used CBD and those that did not. […]

    The study also documented behavioral differences. Dogs that received CBD for extended periods were described as having lower-than-average aggression levels compared to dogs with no CBD use. This pattern suggests that CBD could play a role in reducing aggressive behaviors. Other behavioral traits, such as agitation or anxiety, did not show the same association. “Most canine aggression is related to underlying stress or anxiety — a fight or flight response that kicks in. It is unclear why only aggression but not other types of anxious or agitated behaviors seemed to be improved with CBD treatment,” Albright said. […]

    Science Daily: Scientists studied 47,000 dogs on CBD and found a surprising behavior shift. A massive dog study suggests CBD may ease aggression in aging, ailing pets—though big questions remain

    Frontiers in Veterinary Science: Demographic features, health status, and behavioral changes associated with cannabidiol use in the Dog Aging Project

    Authors: Kendra D. Conrow, Richard S. Haney, Michael H. Malek-Ahmadi, Julia D. Albright, Barbara L. F. Kaplan, Noah Snyder-Mackler, Kathleen F. Kerr, Yi Su, Daniel E. L. Promislow, Emily E. Bray, Maxwell C. K. Leung.

  2. Servetus says:

    Distinctive patterns of brain activity distinguish predispositions for addiction that differ between boys and girls:

    21-Nov-2025 — The roots of addiction risk may lie in how young brains function long before substance use begins, according to a new study from Weill Cornell Medicine. The investigators found that children with a family history of substance use disorder (SUD) already showed distinctive patterns of brain activity that differ between boys and girls, which may reflect separate predispositions for addiction. […]

    To explore these neural differences, the researchers used a computational approach called “network control theory” to measure how the brain transitions between different patterns of activity during rest. “When you lie in an MRI scanner, your brain isn’t idle; it cycles through recurring patterns of activation,” said first author Louisa Schilling, doctoral candidate in the Computational Connectomics Laboratory at Weill Cornell. “Network control theory lets us calculate how much effort the brain expends to shift between these patterns.” This transition energy indicates the brain’s flexibility, or its ability to shift from inward, self-reflective thought to external focus.

    Disruptions in this process have been observed in people with heavy alcohol use and cocaine use disorder, and when under the influence of psychedelics. […]

    The study found that girls with a family history of SUD displayed higher transition energy in the brain’s default-mode network, which is associated with introspection. Compared with girls without such a family history, this elevated energy suggests their brains may work harder to shift gears from internal-focused thinking.

    “That may mean greater difficulty disengaging from negative internal states like stress or rumination,” Schilling said. “Such inflexibility could set the stage for later risk, when substances are used as a way to escape or self-soothe.”

    In contrast, boys with a family history showed lower transition energy in attention networks that control focus and response to external cues. “Their brains seem to require less effort to switch states, which might sound good, but it may lead to unrestrained behavior,” Dr. Kuceyeski said. “They may be more reactive to their environment and more drawn to rewarding or stimulating experiences.”

    Put simply, she said, “Girls may have a harder time stepping on the brakes, while boys may find it easier to step on the gas when it comes to risky behaviors and addiction.” Since the brain differences appeared before any substance use, they may indicate inherited or early-life environmental vulnerability rather than the effects of drugs. […]

    Weill Cornell Medicine: Early brain differences may explain sex-specific risks for addiction

    Natural Mental Health: Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder

    Authors: Louisa Schilling, S. Parker Singleton, Ceren Tozlu, Marie Hédo, Qingyu Zhao, Kilian M. Pohl, Keith Jamison & Amy Kuceyeski

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