Marijuana prohibition and the origins of totalitarianism

In totalitarian societies, marijuana use is a crime of the mind. Its consumption is distinguished from crimes of violence and other types of offenses in that its use symbolizes a flagrant dissent that challenges the authoritarian ideologies prohibiting it.

Marijuana is criminalized not for how users might conduct themselves after smoking it but for what they might contemplate while in a transcendent mental state that could lead to reading banned books or engaging in critical thinking about the drug war and other types of social harms. Thinking is discouraged in totalitarian states just as it is in cults. Those who think effectively and who produce unequivocal answers to social or medical problems are the same people who are capable of exposing the lies imposed upon society by completely monistic applications of toxic ideologies seeking to affect all aspects of human existence. Freethinkers are the natural enemies of totalitarian states.

Governments and legal institutions based largely on dominionistic ideologies like religion or abstract political concepts are known as ideocracies. Uniformity of thought is their ultimate goal. Enforcement typically involves enlisting the help of secret police in addition to creating severe penalties for petty crimes. The goal is to terrorize citizens into absolute silence and obedience. Ideocracies include political factions such as Fascism and Stalinist and Maoist Communism. Religious ideocracies include Islam, Mormonism, Evangelicalism, and Catholicism. Notably, the juridical machinery for enforcing Catholic dogma was achieved through the legalistic methods of the Inquisitions beginning in the 12th century. The Church didn’t apologize for its inquisitorial laws and penalties until Pope John Paul II did so on March 12, 2000, a bit too late in the game to be effective. The Church still hasn’t apologized for its role in the prohibition of marijuana that began in the late 15th century.

The prosecution of thought crimes or heresies is part of the detestation of pluralism, or the condition in which two or more political states or ideologies peacefully coexist together. Heresy is derived from the Greek word hairetikós which means able to choose or form a school of thought, thereby making free choice a forerunner of pluralism. Pluralism is distinctively anti-fascist. As Benito Mussolini noted:

The Fascist conception of the state is all-embracing; outside of it no human or spiritual value may exist, much less have any value. Thus understood, Fascism is totalitarian and the Fascist State, as a synthesis and a unit which includes all values, interprets, develops, and lends additional power to the whole life of a people. — Benito Mussolini, “Dottrina,” in Political Quarterly 4 (July 1933):341–356.

Dictators can behave in ways that fly in the face of traditional ideological, religious and social values. In doing so they make it clear they use popular ideologies as a mere front, a justification for their own existence, a distraction camouflaging a corrupt state or criminal enterprise, as well as an effective way to stay in power.

Leaders contemplating totalitarian rule have not forgotten Mussolini’s fate at the hands of angry mobs. Faith, loyalty and repression of criticism of the regime are believed by dictators to be absolutely essential for retaining power or even staying alive. Endless strings of lies about cannabis and its consumers have been incessantly useful in this way by keeping certain types of people in their designated places while keeping others in places of power.

Social tolerance for drug use can be viewed as a kind of barometer depicting the overall degree of freedom a citizen enjoys. The most severe penalties for cannabis consumption are found in repressive societies like those found in modern Russia and China where long prison terms and even death sentences for its use, transportation or sale are common. Other countries that engage in severe persecution or death penalties for marijuana smugglers include Iran, Singapore, Malaysia, Indonesia, and the United Arab Emirates. Exceptionally long prison sentences for marijuana trafficking are common in countries having traditionally rigid social or political structures such as France, Indonesia, Japan, Venezuela, South Korea, and Saudi Arabia. Censorship is also strongly correlated with totalitarian regimes. Dissenters by their very existence reveal the totalistic construct imposed upon society to be a lie.

With the exception of methamphetamine or Pervitin Nazi Germany was vehemently against recreational marijuana and similar drug use while favoring a fanatical vision of racial and moral purity. Opioid addicts were severely treated and were often sent to concentration camps.

The Germans knew about psychedelic drugs. They knew of Albert Hofmann who synthesized LSD-25 and were familiar with his famous bicycle day on April 19, 1943, when he experimented upon himself by intentionally ingesting 250-micrograms of the psychedelic. The Nazis considered fantasy and absurdity along with harmless hallucinations to be dangerous distractions that could undermine their dreams of a rational and militant society. Nazi anti-drug propaganda would emerge to condemn the Alice in Wonderland story first published in England in 1865 in which Alice eats a magic mushroom and becomes tall or small. They portrayed the classic children’s story as being Jewish drug propaganda designed to corrupt German youth through its embodiment of foreign decadence and subversion of authority.

The forces of old and evil can never defeat marijuana. As citizens become more enlightened about cannabis there is no way they can be made unenlightened. It is truly ironic that dictators would be far less terrified of little Alice and her Wonderland if cannabis and psychedelics were fully legalized at the federal level for adults. Despots would not lose control of their despotic empires as a result. Instead, they will be happy to know that alternative forms of government fraud, waste, corruption and scapegoating will continue as usual and will fill in any of the gaps that result from discontinuing the war on THC. Those who dedicated their lives and careers to amplifying human misery and suffering through the use of censorship and disinformation aiding cannabis prohibition and its drug arrests are likely to be the ones who need to worry. Cause and effect will dictate their political fate and place in history.

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3 Responses to Marijuana prohibition and the origins of totalitarianism

  1. Servetus says:

    Modifications of chemical scaffolds associated with psychedelic compounds can be achieved using ultraviolet light:

    7-Jan-2026 — UC Davis researchers have developed a new method that uses light to transform amino acids — the building blocks of proteins — into molecules that are similar in structure to psychedelics and mimic their interaction with the brain. Like psychedelics, these molecules activate the brain’s serotonin 5-HT2A receptors, which promote cortical neuron growth, and could be candidates to treat a host of brain disorders, such as depression, substance-use disorder and PTSD. However, they don’t trigger hallmark hallucinogenic behavior in animal models. […]

    The research opens the door to a streamlined and environmentally friendly drug discovery platform for new serotonin-effecting drugs that confer the benefits of psychedelics without significantly distorting perception.

    “In medicinal chemistry, it’s very typical to take an existing scaffold and make modifications that just tweak the pharmacology a little bit one way or another,” said study author Trey Brasher, also a Ph.D. student in the Mascal Lab and an affiliate of IPN. “But especially in the psychedelic field, completely new scaffolds are incredibly rare. And this is the discovery of a brand-new therapeutic scaffold.” […]

    The researchers created a library of potentially therapeutic molecules by coupling various amino acids with tryptamine, a metabolite of the essential amino acid tryptophan. They then irradiated these molecules with ultraviolet light to transform them into new compounds of medicinal value.

    Computer simulations were used to test the binding affinity of 100 of these compounds at the 5-HT2A receptor.

    Five candidates were selected for further lab testing to determine efficacy and potency. Efficacies of the selected compounds ranged from 61% to 93%, with the latter representing a full agonist — a compound capable of producing the maximum biological response from the 5-HT2A system.

    The team labeled the full agonist in the group as D5. They expected that administering the compound to mouse models would induce head twitch responses, a hallmark of hallucinogenic-like behaviors.

    However, that wasn’t the case. Despite fully activating the same receptor as psychedelics, D5 didn’t induce head twitch responses.

    “Laboratory and computational studies showed that these molecules can partially or fully activate serotonin signaling pathways linked to both brain plasticity and hallucinations, while experiments in mice demonstrated suppression of psychedelic-like responses rather than their induction,” Beckett and Brasher said. […].

    AAAS Public Science News Release: Creating hallucination-free, psychedelic-like molecules by shining light on life’s basic building blocks — Discovery could lead to new drugs for psychiatric disorders

    Journal of the American Chemical Society: Transforming Amino Acids into Serotonin 5-HT2A Receptor Ligands Using Photochemistry

    Authors: Joseph O. S., Beckett, Ryan Buzdygon, Steven Nguyen, Allison A. Clark, Serena S. Schalk, Lena E. H. Svanholm, Trey J. Brasher, Marc Bazin, Bruna Cuccurazzu, Adam L. Halberstadt, John D. McCorvy, and Mark Mascal.

  2. Servetus says:

    Yoga as an adjunct to chemotherapy can treat opioid withdrawal:

    7-Jan-2026 – In this randomized clinical trial, yoga significantly accelerated opioid withdrawal recovery and improved autonomic regulation, anxiety, sleep, and pain. These findings support integrating yoga into withdrawal protocols as a neurobiologically informed intervention addressing core regulatory processes beyond symptom management. […]

    AAAS Public Science News Release: Yoga for opioid withdrawal and autonomic regulation

    Question: Can yoga as adjuvant therapy accelerate opioid withdrawal recovery and improve autonomic regulation in patients with opioid use disorder?

    Findings: In this randomized clinical trial of 59 male participants with opioid use disorder, those receiving yoga alongside standard buprenorphine treatment achieved withdrawal stabilization 4.4 times faster than controls (median, 5 vs 9 days) and showed significant improvements in heart rate variability, anxiety, sleep, and pain measures.

    Meaning: In this trial, yoga significantly enhanced opioid withdrawal recovery through measurable autonomic and clinical improvements, supporting its integration into withdrawal protocols as a neurobiologically informed intervention. […]

    JAMA Psychiatry: Yoga for Opioid Withdrawal and Autonomic Regulation — A Randomized Clinical Trial

    Authors: Suddala Goutham, MSc; Hemant Bhargav, MD, PhD; Bharath Holla, MD, PhD; Jayant Mahadevan, MD; Ravindra P. Nagendra, MD, PhD; Nishitha Jasti, PhD; Venkata Lakshmi Narasimha, MD, DM; Urvakhsh Meherwan Mehta, MD, PhD4; Shivarama Varambally, MD; Ganesan Venkatasubramanian, MD, PhD; Prabhat Chand, MD; Bangalore Nanjundiah Gangadhar, MD, DSc; Kevin P. Hill, MD; Matcheri Keshavan, MD; Pratima Murthy, MD.

  3. Servetus says:

    Gene therapy alternative for chronic pain might replace use of opioids:

    7-Jan-2026 –Philadelphia—A preclinical study uncovered a new gene therapy that targets pain centers in the brain while eliminating the risk of addiction from narcotics treatments, a breakthrough which could provide hope for the more than 50 million Americans living with chronic pain.

    Dealing with chronic pain can feel like listening to a radio where the volume is stuck at maximum volume, and no matter what you do, the noise never seems to dull or lessen. Opioid medications, like morphine, work by turning down the volume, but they also affect other parts of the brain, sometimes leading to dangerous side effects or even addiction.

    The potential new gene therapy is akin to a volume knob that only turns down the pain station and leaves everything else untouched, according to research from teams at the University of Pennsylvania Perelman School of Medicine and School of Nursing, along with collaborators at Carnegie Mellon University and Stanford University. […]

    Morphine is a narcotic derived from opium with a high potential for abuse because patients who use it can develop tolerance, requiring higher and higher doses to achieve the same reduction in pain. By imaging brain cells that act as pain trackers, the team uncovered new insight into how morphine eases suffering.

    From there, they built a mouse-model behavioral platform driven by artificial intelligence (AI) that tracks natural behaviors, creates a readout of pain levels, and helps gauge how much treatment is needed to alleviate the pain.

    This readout, used as a sort of map, allowed the team to design a targeted gene therapy that mimics morphine’s beneficial effects but avoids its addictive ones while delivering an “off switch” specifically for pain felt in the brain. When activated, this switch provides durable pain relief without affecting normal sensation or triggering reward pathways that can lead to addiction.

    “To our knowledge, this represents the world’s first CNS-targeted gene therapy for pain, and a concrete blueprint for non-addictive, circuit-specific pain medicine,” Corder said. […]

    The results are the culmination of more than six years of investigation powered by a National Institutes of Health New Innovator Award that allowed Corder and his colleagues to research the mechanisms of chronic pain.

    In 2019, 600,000 deaths were attributed to drug use, with 80 percent of those related to opioids. Nearly half of Philadelphians who responded to a 2025 Pew survey reported knowing someone with opioid use disorder (OUD). One-third knew someone who had died as the result of an overdose.

    Chronic pain, known to some as a ‘silent epidemic’ impacts approximately 50 million Americans, costing upward of $635 million annually in direct medical expenses and indirect costs from lost productivity, including missed work and reduced earning capacity. Now, these findings have the potential to help ease that pain—or, turning down the noise—for some, should the science hold through additional testing and into clinical trials.

    The team is moving forward with Michael Platt, PhD, the James S. Riepe University Professor, Professor of Neuroscience, Professor of Psychology, on the next phase of work as a hopeful bridge toward future clinical trials.

    “The journey from discovery to implementation is long, and this represents a strong first step,” Platt said. “Speaking both as a scientist and as a family member of people affected by chronic pain, the potential to relieve suffering without fueling the opioid crisis is exciting.” […]

    AAAS Public Science News Release: Gene therapy ‘switch’ may offer non-addictive pain relief — New approach targets only pain signals while leaving the rest of the brain untouched

    Nature: Mimicking opioid analgesia in cortical pain circuits

    Authors: Corinna S. Oswell, Sophie A. Rogers, Justin G. James, Nora M. McCall, Alex I. Hsu, Gregory J. Salimando, Malaika Mahmood, Lisa M. Wooldridge, Meghan Wachira, Adrienne Y. Jo, Raquel Adaia Sandoval Ortega, Jessica A. Wojick, Katherine Beattie, Sofia A. Farinas, Samar N. Chehimi, Amrith Rodrigues, Jacqueline W. K. Wu, Lindsay L. Ejoh, Blake A. Kimmey, Emily Lo, Ghalia Azouz, Jose J. Vasquez, Matthew R. Banghart, Kevin T. Beier, Kate Townsend Creasy, Richard C. Crist, Charu Ramakrishnan, Benjamin C. Reiner, Karl Deisseroth, Eric A. Yttri & Gregory Corder.

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