MKUltra resurfaces as a new HBO series

CIA mind control experiments that exposed willing and more often unwilling people to mind-altering chemicals are the focus of an HBO series now in early production by David Chase. Chase is best known as the creator of the Emmy-winning mob drama The Sopranos. His latest drama series is based on John Lisle’s new book Project Mind Control: Sidney Gottlieb, the CIA, and the Tragedy of MKUltra.

John Lisle’s book goes into greater detail than previous MKUltra exposés. The reader gets to know the arch-chemist Sidney Gottlieb (aka The Black Sorcerer), who headed MKUltra while working at Langley, Virginia. On January 30, 1973, Gottlieb burned all his own files related to the secret drug dosing program. He was driven out of the CIA during the Nixon Watergate scandal. Gottlieb’s testimony before the Church and Pike Committees survived, and it is this testimony, along with seven displaced boxes of rediscovered MKUltra files, that is vividly revealed by Lisle.

One of the major mysteries surrounding MKUltra involves the circumstances of the death of CIA operative Frank Olson. Many have speculated that Olson was tossed out of a 13th-story hotel window by fellow CIA colleagues who feared he would panic and reveal details of the LSD experiments and MKUltra to the public. The fall was recounted by the Statler Hotel’s doorman, who yelled:

“We got a jumper, we got a jumper!” He later described Olson’s fall as “like the guy was diving, his hands out in front of him, but then his body twisted and he was coming down feet first, his arms grabbing at the air above him.” (p. 49)

Olson wasn’t the only fatality involving MKUltra. Gottlieb was a real-life super spy who could outshine any James Bond villain with scores of super-deadly brainwashing tricks all commissioned in the name of national security. He attempted to use psychedelic drugs to create an American-controlled Manchurian Candidate before the Communists could create one of their own. One witness to the Gottlieb family’s very private lifestyle was a young family friend of Peter Gottlieb named Elizabeth:

One day that summer, we were out at the house swimming. The parents had gone to the store to buy food for dinner, and Peter goes, kind of conspiratorially, “Come here. I want to show you something.” He takes me into his father’s den, his library, and says, “Turn around.” He did something—he didn’t want me to see what he did—and the wall of books opened up. Behind it was all this stuff. Weapons—I couldn’t tell which kind, but guns. There was other stuff back there. It was like a secret compartment. I couldn’t tell which kind, but guns. There was other stuff back there. It was like a secret compartment. I asked him, “What is that for?” He closed it back up quickly and said, “You know, my father has a price on his head.” I said, “Why, is he a criminal?” He said, “No, he works for the CIA.” Then he said, “You know, my dad has killed people. He made toothpaste to kill someone.” Later on he told me, “Don’t tell anyone that you were in there, and don’t ever tell anyone you know that my father kills people.” (p. 154).

If the Sopranos episodes are any indication of what to expect with the MKUltra production, David Chase’s new series should be just as outstanding and win just as many awards while providing a fascinating glimpse inside the CIA’s covert drug wars.

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6 Responses to MKUltra resurfaces as a new HBO series

  1. Servetus says:

    CBD for elderly dogs is proving effective in reducing canine aggression due to old-age anxiety and irritabilities (fight or flight) and in dealing with other health related problems:

    27 November 2025 — CBD is already used by many people for issues such as chronic pain, nausea, and inflammation. A new analysis suggests that dogs might also experience some of these benefits. Researchers in the US examined information from the Dog Aging Project to better understand the characteristics, health patterns, and behavior of dogs that received CBD or hemp supplements. […]

    “Behaviorally, dogs given CBD products for multiple years are initially more aggressive compared to dogs not receiving those products, but their aggression becomes less intense over time,” said senior author Dr. Maxwell Leung, an assistant professor and the director of Cannabis Analytics, Safety and Health Initiative at Arizona State University.

    “This long-term behavioral change highlights the potential of CBD as a therapy for canine behavioral issues,” added co-author Dr. Julia Albright, an associate professor at the College of Veterinary Medicine at the University of Tennessee. […]

    This research represents the most extensive effort so far to investigate CBD use among pet dogs in the US. The team relied on the Dog Aging Project, a long-term community science initiative in which owners provide yearly updates on their pets’ diet, lifestyle, health, and living conditions. A total of 47,355 dogs were included, with data collected through annual surveys between 2019 and 2023.

    Owners detailed how often their dogs consumed CBD or hemp products. Frequent users received a supplement every day, while infrequent users were given supplements less often than once a day. Owners could also indicate that their dogs had never been given CBD. […]

    Several health issues were linked to higher CBD use. The strongest association was seen in dogs with dementia (18.2%), followed by those with osteoarthritis joint problems (12.5%) and those diagnosed with cancer (10%).

    Dogs living in states where human medical cannabis is legal were also more likely to receive CBD. This may reflect how owners’ attitudes toward cannabis influence their decisions for their pets. Male dogs were given CBD more often, with a 9% higher likelihood than female dogs. However, activity levels did not differ significantly between dogs that used CBD and those that did not. […]

    The study also documented behavioral differences. Dogs that received CBD for extended periods were described as having lower-than-average aggression levels compared to dogs with no CBD use. This pattern suggests that CBD could play a role in reducing aggressive behaviors. Other behavioral traits, such as agitation or anxiety, did not show the same association. “Most canine aggression is related to underlying stress or anxiety — a fight or flight response that kicks in. It is unclear why only aggression but not other types of anxious or agitated behaviors seemed to be improved with CBD treatment,” Albright said. […]

    Science Daily: Scientists studied 47,000 dogs on CBD and found a surprising behavior shift. A massive dog study suggests CBD may ease aggression in aging, ailing pets—though big questions remain

    Frontiers in Veterinary Science: Demographic features, health status, and behavioral changes associated with cannabidiol use in the Dog Aging Project

    Authors: Kendra D. Conrow, Richard S. Haney, Michael H. Malek-Ahmadi, Julia D. Albright, Barbara L. F. Kaplan, Noah Snyder-Mackler, Kathleen F. Kerr, Yi Su, Daniel E. L. Promislow, Emily E. Bray, Maxwell C. K. Leung.

  2. Servetus says:

    Distinctive patterns of brain activity distinguish predispositions for addiction that differ between boys and girls:

    21-Nov-2025 — The roots of addiction risk may lie in how young brains function long before substance use begins, according to a new study from Weill Cornell Medicine. The investigators found that children with a family history of substance use disorder (SUD) already showed distinctive patterns of brain activity that differ between boys and girls, which may reflect separate predispositions for addiction. […]

    To explore these neural differences, the researchers used a computational approach called “network control theory” to measure how the brain transitions between different patterns of activity during rest. “When you lie in an MRI scanner, your brain isn’t idle; it cycles through recurring patterns of activation,” said first author Louisa Schilling, doctoral candidate in the Computational Connectomics Laboratory at Weill Cornell. “Network control theory lets us calculate how much effort the brain expends to shift between these patterns.” This transition energy indicates the brain’s flexibility, or its ability to shift from inward, self-reflective thought to external focus.

    Disruptions in this process have been observed in people with heavy alcohol use and cocaine use disorder, and when under the influence of psychedelics. […]

    The study found that girls with a family history of SUD displayed higher transition energy in the brain’s default-mode network, which is associated with introspection. Compared with girls without such a family history, this elevated energy suggests their brains may work harder to shift gears from internal-focused thinking.

    “That may mean greater difficulty disengaging from negative internal states like stress or rumination,” Schilling said. “Such inflexibility could set the stage for later risk, when substances are used as a way to escape or self-soothe.”

    In contrast, boys with a family history showed lower transition energy in attention networks that control focus and response to external cues. “Their brains seem to require less effort to switch states, which might sound good, but it may lead to unrestrained behavior,” Dr. Kuceyeski said. “They may be more reactive to their environment and more drawn to rewarding or stimulating experiences.”

    Put simply, she said, “Girls may have a harder time stepping on the brakes, while boys may find it easier to step on the gas when it comes to risky behaviors and addiction.” Since the brain differences appeared before any substance use, they may indicate inherited or early-life environmental vulnerability rather than the effects of drugs. […]

    Weill Cornell Medicine: Early brain differences may explain sex-specific risks for addiction

    Natural Mental Health: Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder

    Authors: Louisa Schilling, S. Parker Singleton, Ceren Tozlu, Marie Hédo, Qingyu Zhao, Kilian M. Pohl, Keith Jamison & Amy Kuceyeski

  3. Servetus says:

    Iron fortified charcoal or “biochar” made from hemp agricultural waste can be used to clean up contaminated soil:

    1-Dec-2025 — Iron fortified hemp biochar made from agricultural waste can significantly cut the amount of “forever chemicals” that move from contaminated soil into food crops, according to a new study on radishes grown in PFAS polluted soil. […]

    Per and polyfluoroalkyl substances (PFAS) are extremely persistent industrial chemicals that can move through soil, water and air and build up in crops and people. In this greenhouse study, researchers tested whether biochar made from hemp plants, and enhanced with iron, could lock PFAS in place and keep them out of edible radish bulbs. They found that iron fortified hemp biochar lowered PFAS levels in radish tissues and reduced overall plant uptake compared with unamended soil and with plain biochar. […]

    Soil at the field site contained about 576 nanograms of total PFAS per gram, dominated by PFOS which contributed roughly 60 percent of the total burden. Biochar made at the lowest temperature (500 degrees Celsius) had the highest specific surface area and more oxygen containing functional groups, which favored PFAS retention compared with material made at higher temperatures. Fortifying biochar with iron further increased surface area and pore volume and introduced iron oxide and hydroxide sites that can attract anionic PFAS molecules.

    Across all treatments, radishes grown in the contaminated soil without amendments showed strong accumulation of short chain PFAS, with bioaccumulation factors above 1 and particularly high values for short chain carboxylic and sulfonic acids. When the soil was amended with iron fortified hemp biochar produced at 500 degrees, total PFAS in whole radish plants dropped by about 37 percent compared with unamended soil, and by nearly 46 percent relative to plants grown with non fortified biochar. In the edible bulb, iron fortified biochar cut PFAS bioaccumulation by about 25.7 percent and produced especially large reductions for several short chain sulfonic and carboxylic acids. […]

    Analyses showed that increasing pyrolysis temperature shrank the biochar’s surface area and pore volume and reduced the abundance of reactive surface functional groups, all of which limited PFAS sorption. In contrast, iron fortification boosted porosity and created additional positively charged and hydrophilic sites that support electrostatic attraction, ligand exchange, hydrogen bonding and complex formation with PFAS head groups while maintaining a hydrophobic carbon backbone that interacts with the fluorinated chains. The authors conclude that this combination of physical and chemical mechanisms allows iron fortified hemp biochar to hold PFAS more strongly in soil pore spaces, lowering the freely dissolved fraction available for plant uptake. […]

    The study highlights that even root vegetables like radish can accumulate substantial amounts of short chain PFAS when grown in contaminated fields, raising concerns for food safety in affected farming regions. By demonstrating that a relatively low dose of iron enriched biochar made from an agricultural residue can both improve soil properties and reduce PFAS transfer into edible tissues, the work points to a practical soil management strategy for reducing PFAS exposure through diet. The authors note that future research should examine long term field performance, potential effects on soil microbes and PFAS transformation, and whether similar approaches can protect other crop species and soils with different PFAS mixtures. […]

    Environmental and Biogeochemical Processes: Iron fortified hemp biochar helps keep “forever chemicals” out of radishes and the food chain

    Authors: Trung Huu Bui, Mandeep Kaur, Nubia Zuverza-Mena, Sara L. Nason, Christian O. Dimkpa, Jasmine P. Jones & Jason C. White.

  4. Servetus says:

    Psilocybin and the rabies virus are used to explain the rewiring of mental circuits:

    5-Dec-2025 – An international collaboration led by Cornell University researchers used a combination of psilocybin and the rabies virus to map how – and where – the psychedelic compound rewires the connections in the brain.

    Specifically, they showed psilocybin weakens the cortico-cortical feedback loops that can lock people into negative thinking. Psilocybin also strengthens pathways to subcortical regions that turn sensory perceptions into action, essentially enhancing sensory-motor responses. […]

    The project is the latest by Alex Kwan, professor of biomedical engineering and the paper’s senior author. Kwan’s lab studies the ways psychiatric drugs such as psilocybin, ketamine and 5-MeO-DMT rewire the brain’s neurological circuitry, with the goal of developing therapeutic treatments for depression. […]

    …we use the rabies virus to read out the connectivity in the brain, because these viruses are engineered in nature to transmit between neurons. That’s how they’re so deadly. It jumps a synapse and goes from one neuron to another […]

    Initially Kwan expected to find connections between one or two regions of the brain, but he was surprised to discover psilocybin’s rewiring involved the whole brain.

    “This is really looking at brain-wide changes,” he said. “That’s a scale that we have not worked at before. A lot of times, we’re focusing on a small part of the neural circuit.” […]

    AAAS Public Science News Release: Dose of psilocybin, dash of rabies point to treatment for depression

    Cell: Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks

    Authors: Quan Jiang, Ling-Xiao Shao, Shenqin Yao, Neil K. Savalia, Amelia D. Gilbert1, Jack D. Nothnagell, Guilian Tian, Tin Shing Hung, Hei Ming Lai, Kevin T. Beier, Hongkui Zeng, Alex C. Kwan.

  5. Servetus says:

    Genetic engineering promises to someday create a phone app that can detect coded genes being used as identifying markers in agricultural produce such as tomatoes. The same identifying markers could be employed for marijuana for identifying specific commercial grades of marijuana or the product’s country of origin.

    17-Dec-2025 – Imagine a container of tomatoes arriving at the container terminal in Aarhus. The papers state that the tomatoes are from Spain, but in reality, we have no way of knowing if that is true.

    That is, unless we take a sample and have it analyzed in a laboratory, where scientists use DNA markers to determine whether the tomato is Spanish, South American or Chinese. This is both time-consuming and expensive.

    But thanks to a scientific breakthrough in the research group of Professor Alexander Zelikin at Aarhus University, we will be able to examine tomatoes a lot quicker and cheaper, using special light producing proteins and our phones camera. Not right now, but in the near future. […]

    In Alexander Zelikin’s laboratory, they engineer molecules and cells. In some instances his team designs new molecules and install these into mammalian cells to bring new functions into the cell. But they also strive to build synthetic cells from scratch, one chemical building block at the time.

    “We will hardly create new life this way any time soon. This is not why we are doing it. We are doing it to better understand and control natural cells.”

    “Our primary goal is to control the activity of molecules in space and time, inside and outside of the cell. Specifically we focus on enzymes that can create ATP, which is the cell’s fuel, and polymerases, which the cell uses to build RNA and DNA.”

    By doing this kind of research his team gets a deeper understanding of how cellular mechanisms work. And it is through this research they learned how to engineer proteins that generate light when certain DNA sequences are present – as in the example with the tomatoes. […]

    Alexander Zelikin’s research group strives to build intelligent synthetic cells, which are programmed to react in specific ways to the environment.

    “For us, the most fundamental challenge is to design the mechanisms of communication, so that the artificial cells can communicate with the environment, understand the information they receive and react to it.” […]

    AAAS Public Science News Release: Breakthrough: Now we can detect specific DNA with a phone — A Danish research group has designed proteins that search for specific DNA sequences and produce light if they find them. A light that a phone’s camera easily captures

    Nature Communications: Activation of enzymatic catalysis via nucleic acid hybridization affords synergistic coupling of specificity, potency, and signal amplification

    Authors: Mireia Casanovas Montasell, Lou M. V. Raeven, Mathilde Ravn Malm, Jan C. M. van Hest & Alexander N. Zelikin.

  6. Servetus says:

    Stressed-out rats like marijuana:

    It isn’t just people — when given the chance rats may also use cannabis to cope with stress, according to a study by researchers at Washington State University.

    …the study set out to investigate which animals would actively seek out cannabis and why. The researchers discovered that rats with naturally higher stress levels were much more likely to repeatedly self-administer the commonly used recreational drug.

    “We ran rats through this extensive battery of behavioral and biological tests, and what we found was that when we look at all of these different factors and all the variables that we measured, stress levels seem to matter the most when it comes to cannabis use,” said Ryan McLaughlin, associate professor in WSU’s College of Veterinary Medicine.

    …researchers examined a wide range of characteristics, including social behavior, sex, thinking abilities, reward sensitivity, and arousal. From these measurements they built a behavioral profile for each rat. Over a three-week period, the animals were then observed for one hour a day while they had a choice to self-administer cannabis by poking their nose into a vapor port, which released a three-second burst of cannabis vapor into an air-tight chamber.

    During each daily session, the student researchers recorded how many “nose-pokes” each rat performed. They then compared those counts with baseline stress hormone levels and found a clear relationship: rats that poked more often tended to have higher starting levels of stress hormones. […]

    The study also uncovered strong links between how often rats self-administered cannabis and their performance on tests of “cognitive flexibility,” which refers to the ability to adapt when rules or conditions change.

    “Animals that were less flexible in shifting between rules, when we tested them in a cognitive task, tended to show stronger rates of cannabis-seeking behavior,” he said. “So, animals that rely more heavily on visual cues to guide their decision making, those rats, when we tested their motivation to self-administer cannabis vapor, were also very highly motivated rats.” […]

    …the researchers found another pattern involving a combination of high morning corticosterone levels and low endocannabinoid levels, which was also associated with cannabis self-administration, although this link was weaker than the effect of baseline stress. […]

    ScienceDaily: Stressed rats keep returning to cannabis and scientists know why

    Neuropsychopharmacology: Identifying behavioral and biological predictors of cannabis vapor self-administration in rats

    Authors: Ginny I. Park, Alexandra N. Malena, Nicholas C. Glodosky, Zachary D. G. Fisher, Carrie Cuttler, Savannah H. M. Lightfoot, Samantha L. Baglot, Cayden Murray, Matthew N. Hill, Ryan J. McLaughlin.

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