Wine versus marijuana and drug war dogmas

Dogma is an ancient Greek word that originally meant opinion until it was repurposed in 1534 to be an authoritarian mandate with legal consequences for anyone questioning it. It was the same year the Church of England split from the Roman Catholic Church. In the Reformation, criticizing dogma became heresy. Rejecting it altogether could lead to lethal penalties.

Fear mongering and foreboding over dogmas involving marijuana use began for Western culture in 1484 when Pope Innocent VIII issued a papal mandate rejecting cannabis consumption. The Catholic Church reigned over the medical profession at the time. Besides rejecting cannabis as a medicine, the pope also believed that by drinking children’s blood he could alleviate or prevent some of his health problems. Among his other faults Innocent VIII is remembered for initiating the Catholic witch hunts and for bankrupting the papacy through nepotism, simony and extravagant spending. He used Church funds to support his illegitimate children with titles and estates.

Good Catholics were subsequently expected to believe cannabis was a witch’s tool used to hereticate the soul. Alleged witches in the late Middle Ages could be male or female. In most cases they were female medical practitioners at odds with the male Catholic clergy who ruled the Western healing traditions. The clergy were not allowed to take money for their medical services for fear it could lead to corruption in the Church. More medical practitioners were needed so in due course the job of medical doctor emerged to become a profitable secular career in which the clergy might participate. Nuns could still work as nurses for example.

Apart from opium and alcohol, medicines in the medieval Christian era were viewed with moral suspicion. The clergy believed a demonic force was the enabling agent if a drug got people high. The ability to alter consciousness resulted in the humble marijuana plant being elevated to the lofty position of the supernatural to become one among many demons thought to exist everywhere. By contrast, wine is sacred for the Catholic Church. Wine is central to the Eucharist, where bread and wine undergo a ceremonial metamorphosis to become the body and blood of Christ that is symbolically cannibalized by parishioners. The first communion age is about 7 years-old, or when a child is considered mature enough to sip wine.

Wine has always played a substantial role in Christian history. According to scripture Noah had a vineyard. Benedictines and Cistercians are regarded as the early pioneers of excellent winemaking. A Benedictine monk, Dom Pierre Pérignon, invented champagne. St. Junípero Serra brought viticulture to California by planting grapes at Catholic missions. His miraculous efforts grew to become the state’s $84.5 billion per year wine industry. Other religious groups in which wine is fundamental to their ancient religious ceremonies include Judaism and Shinto.

Fear of cannabis and psychedelic drugs by modern cults, sects, and mainstream religions originates with a belief that psychoactive drugs can stimulate the mind and imagination in ways that might weaken dogmatic authority. If the critical-thinking accusation is correct, it would follow that marijuana and psilocybin could be employed as medical treatments for religious hysteria and extremism. Unfortunately, neither marijuana nor psilocybin show signs of reducing dogmatic hostilities, while there exists evidence that psilocybin can enhance or stimulate religious experiences. More research is needed. Either way, the wine industry is safe.

The evidence connecting religious dogma to marijuana prohibition is best illustrated by those who favor cannabis and those who don’t. Recent polls suggest that religious people are more likely to practice moral absolutism regarding marijuana use, whereas marijuana users are more likely to accept moral relativism. In a 2021 Pew poll only 44-percent of white Protestants and 58-percent of white Catholics favored full marijuana legalization compared to 88-percent of atheists who favored all uses of cannabis. The large opinion gaps indicate that religion, emotion and social norms play a more important role in cannabis prohibition than suspected health concerns. Marijuana prohibition is what many always suspected it to be, a religious dogma backed by falsehoods.

As a legal instrument, marijuana prohibition is required to fall under a specific set of rules that sidestep religious decision making. The U.S. Constitution’s establishment clause insists that Congress not create a national church or endorse purely religious practices. Despite this restriction the government and courts often side with religions, sects and cults regarding their uniquely unscientific rejection of illicit drugs. Other legal safeguards add weight to the establishment clause. Article VI of the Constitution states that no religious test shall be required as a qualification for any office or public trust. Because marijuana criminalization is for all intents and purposes a religiously biased prohibition, a religious test occurs by default when a government agency rejects employment applications because an applicant used marijuana in the recent past, either for religious, medical or recreational purposes.

Marijuana prohibition ignores a person’s right to medical privacy. Privacy in America is protected by the First Amendment’s freedom of association and expression, the Fourth Amendment’s protections against unreasonable searches and seizures, the Fifth Amendment’s protections against self-incrimination, the Ninth Amendment’s recognition of rights not specifically enumerated, and the Fourteenth Amendment’s due process clause used to protect individual autonomy. Medical record privacy is assured by the Health Insurance Portability and Accountability Act of 1996 (HIPAA).

A big problem for law enforcement is that no victim acting as a plaintiff exists in marijuana arrests. Unusual and often extreme measures are therefore required in apprehending violators. Sometimes the measures are illegal, such as entrapment. For instance, entrapment occurs when a person in ill health is forced to use marijuana medicinally but is trapped into committing a violation of the law by not being allowed to possess it legally.

Other enforcement problems exist. Drugs can be planted on a person during a police encounter. Drug laws can be used to target otherwise law-abiding people for political purposes. Drug accusations can be used for personal leverage, e.g., threatening to expose private information or take away children. Marijuana violations have been used as an excuse to deny government monetary assistance to Americans who suffered property damage in wildfires. One marijuana violation can cause a person to lose their government security clearance or be kicked out of the military. Drug prohibition can be an aid in upholding a totalitarian government that persecutes its opponents and private citizens to remain in power.

It’s often argued that legislating morality is impossible. Marijuana and alcohol prohibition are good examples of why it is impossible. Science research consistently points to the health benefits for cannabinoids such that little remains to justify cannabis prohibition but an archaic moral system. Federal drug enforcement agencies are aware of the problems and contradictions of the drug war. The continuing desire to disrupt or eliminate suspected moral enemies appears to dominate all other concerns.

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5 Responses to Wine versus marijuana and drug war dogmas

  1. As L. Neil Smith once said, “If the Fourth and Fifth Amendments were enforced, every last judge and prosecutor in America would be in jail–and America would be a cleaner, healthier place for it.”
    I dare any drug prohibitionist such as Jeff Landry, Liz Murrill, Sid Gautreaux, Benjamin Clapper, the FRC dipshits (E. G. Perkins, Blackwell, and Bauwen), Joe LoPinto, Jesse Watters, Lance “Blue Lives Matter” Harris, Mike Ranatza, E. Pete Adams, Benjamin White, Beth Mizell, Ken Paxton, Greg Abbott, James Uthmeyer, or Ann Coulter to debate Scott Horton. They would not last.

  2. Servetus says:

    Psychiatry complains of a lack of properly conducted psychiatric research on psilocybin:

    5-Nov-2025 — The expanding use of unregulated psilocybin mushrooms, combined with high variability in composition and common co-use with other substances, raises urgent public health concerns. Existing clinical data are insufficient to guide harm reduction or policy. There is a pressing need to pivot from controlled efficacy trials to real-world research on psilocybin use, including public education, potency testing, and age-specific risk assessment. […]

    AAAS Public Science News Release:
    Psilocybin outside the clinic

    JAMA Psychiatry: Psilocybin Outside the Clinic — Public Health Challenges of Increasing Publicity, Accessibility, and Use

    Authors: Kent E. Hutchison, PhD; Jake F. Hooper, BS; Hollis C. Karoly, PhD.

  3. Servetus says:

    CBD’s effects on the brain and nervous system are clarified:

    7-Nov-2025 — Over the past decade, the use of cannabis products for pain management has increased, in part because in 2018 Congress signed a law removing hemp from the federal Controlled Substances Act, thereby legalizing hemp-derived CBD. Today, it is most commonly found in oil form, as well as in lotions and cosmetics, and it is widely understood that CBD does not cause a ‘high’. However, what CBD does in the human body and brain is not well understood. Currently, the Food and Drug Administration has only approved CBD as an adjunctive treatment for certain forms of epilepsy, and it is not recommended for use during pregnancy.

    “We need to understand more about this compound, what mechanisms it interacts with in the brain, its impact on the body, and whether it is a potentially safer solution for treating the chronic pain epidemic,” said Kuan Hong Wang, PhD, professor of Neuroscience and member of the Del Monte Institute for Neuroscience at the University of Rochester, whose lab in collaboration with researchers at Harvard Medical School and Boston Children’s Hospital, recently discovered that in mice, they could effectively deliver CBD to the brain for neuropathic pain relief with no adverse side effects. […]

    The first hurdle researchers had to cross was the blood-brain barrier. This part of our anatomy does an incredible job of keeping our brain healthy, as it essentially acts as a protective force field around the brain. Because of this barrier and the fact that CBD does not dissolve well in water, very little CBD reaches the brain when taken in its common oil form. Staff scientist Jingyu Feng, PhD, in the Wang Lab, and the first author of the study, helped develop the delivery mechanism: inclusion-complex-enhanced nano-micelle formulation or CBD-IN. CBD-IN is a method that encapsulates CBD molecules within nano-micelles or water-soluble spheres that are considered safe in food and drugs.

    Researchers found that when CBD-IN was given to mice, it provided pain relief within 30 minutes, and with none of the common adverse side effects, like loss of movement, balance, or memory, that often occur when taking conventional pain drugs. “The pain relief also lasted through repeated use,” said Feng. “We did not see its effect wear off over time.” […]

    Using imaging and genetic mapping tools, researchers revealed that when CBD-IN is ingested by mice, it calms overactive nerve circuits in the areas of the brain and spinal cord responsible for sensing touch and pain. This calming effect only occurs where abnormal activation is present, like after a nerve injury. Importantly, CBD-IN does not affect healthy neurons.

    Researchers were surprised to discover that the pain-relieving effect did not rely on the typical cannabinoid receptors (CB1 and CB2) that THC and other cannabis compounds target in the body. “Instead, CBD-IN seems to influence broader electrical and calcium signaling in nerve cells, offering a new way to control nerve hyperactivity without triggering the ‘high’ or dependency risks associated with traditional cannabinoids or opioids,” Feng said.

    “The broader implication of this research is that nanotechnology can make natural compounds like CBD more effective and precise,” said Wang, co-senior author of this research. “By enhancing brain delivery and targeting only disease-related neural overactivity, this strategy could open new doors for treating chronic pain and possibly other neurological disorders, such as epilepsy or neurodegenerative diseases, where abnormal nerve activity plays a central role.” […]

    AAAS Public Science News Release: Research hints at the potential of pain relief with CBD

    Cell Chemical Biology: Rapid suppression of neuropathic pain and somatosensory hyperactivity by nano-formulated cannabidiol

    Authors: Jingyu Feng, Jessica Page, Leeyup Chung, Zhigang He, Kuan Hong Wang.

  4. Servetus says:

    Grant and award announcement for research that will investigate alcohol use disorder (AUD),

    7-Nov-2025 — Alcohol use disorder, characterized by uncontrollable alcohol consumption due to physical and psychological dependence, affects approximately 14.1 million people in the U.S. Despite the related public health issues and associated economic costs — an estimated $249 billion annually — pharmacological treatment options for AUD have advanced only minimally since 2004. This underscores the urgent need for novel therapeutic targets. […]

    Increased interferon (proteins released in cells due to a virus) signaling and activation of inflammatory pathways have been established …with AUD and alcohol-preferring animals. However, the mechanisms to reverse or modify these neuroimmune abnormalities are not well understood, creating a critical need to identify new neurobiological factors for potential intervention.

    “Neuroinflammation has been observed in the brains of individuals with AUD,” Li said. “In this pilot study, we will explore a new idea: whether there is a connection between ERVs and the neuroinflammation seen in AUD in a pilot sample.”

    Although ERVs are silenced in most cases, certain environmental triggers can reactivate some of them. Once reactivated, host cells may recognize some ERVs as foreign due to their viral nature, which triggers inflammatory immune responses. […]

    ERVs make up eight percent of the human genome and consist of more than 400,000 distinct elements derived from ancient retroviral infections that have integrated into human genomes. These sequences can disrupt host cell functions and may reactivate in response to various environmental triggers.

    “Our proposed model suggests that, although typically silenced, specific ERVs can be transcriptionally activated by chronic and excessive alcohol exposure, leading to inflammatory immune dysregulation in AUD,” Li explained. “We aim to investigate the role of ERV expression and ERV genotypes in the AUD pathophysiology through our innovative bioinformatics platform, a process which enables precise genotyping and expression quantification of individual ERVs.” […]

    AAAS Public Science News Release: NIH-funded exploratory study to seek possible targets for treating alcohol use disorder

  5. Servetus says:

    Low dosage THC reduces harmful side effects and inflammations caused by HIV and its therapies:

    6-Nov-2025 – Long-term, low doses of THC mitigate many harmful side effects and inflammation caused by HIV and antiretroviral therapy (ART), according to new research from Texas Biomedical Research Institute. […]

    The benefits included increased production of the chemical serotonin, while inflammation, cholesterol and harmful secondary bile acids were all reduced. Notably, levels of ART drugs, which can be toxic to the liver over time, were lower in blood plasma without affecting viral suppression. […]

    ART does a very good job at suppressing HIV to undetectable levels. Once a death sentence, HIV is now a manageable disease. But as people live longer with HIV, they are experiencing substantial side effects from the virus and the medications.

    “People living with HIV experience chronic inflammation, which leads to many co-morbidities such as cardiovascular disease, liver disease and some neurological diseases,” said Professor Mahesh Mohan, DVM, Ph.D. “Our lab is interested in finding solutions to help address this.”

    The current study builds on previous research in Dr. Mohan’s lab into therapeutic uses of low-dose THC – similar to FDA-approved THC medications for treating seizures, chemotherapy-induced nausea and vomiting, and AIDS-related anorexia and weight loss. […]

    “There were no downsides,” Dr. Premadasa said. “I kept looking because I couldn’t believe it could all be good, but I really could not find any negative impacts.” […]

    Another key finding: serotonin, an important neurotransmitter that regulates mood along with a host of other functions, including sleep and digestion, was much higher in the THC-treated group compared to controls.

    The increases were observed across multiple facets of serotonin production, which occurs primarily in the gut. Specifically, Dr. Premadasa found higher numbers of specialized enterochromaffin cells that produce serotonin and more good gut bacteria (L. plantarum) that facilitate serotonin production in the THC-treated group, compared to the control group. She also observed significant upregulation of serotonin receptors in the THC-treated group, which are required to convey signals from the gut to the brain via the vagus nerve, enhancing the gut-brain axis communication.

    “This is an exciting finding that could be investigated further to address a range of conditions related to low serotonin levels, including depression, memory loss, brain fog and perhaps long-COVID symptoms,” Dr. Mohan said. “Reduced serotonin levels are known to disrupt signaling between the gut and brain, so improving those serotonin levels and communication with low-dose cannabinoids could offer a new or complementary treatment approach.” […]

    The THC-treated group also had a healthier, more balanced gut microbiome with higher levels of good gut bacteria, including species that help lower cholesterol. There were lower levels of secondary bile acids, which are toxic at high levels and can lead to blockage in the liver bile ducts (cholestasis), inflammation and scarring (cirrhosis) and end-stage liver disease.

    Other metabolites were increased that help break down fatty acids, which helps reduce plaque that clogs arteries, thus improving cardiovascular health. In fact, levels of plaque-causing fatty acids, called long-chain acetylcholines, had returned to pre-infection levels in the THC-treated group, while the control group continued to have significantly elevated levels of harmful fatty acids. […]

    Texas Biomedical Research Institute: Low-dose THC reduces side effects of HIV treatment…Texas Biomed researchers find promising benefits for gut health, serotonin levels and more.

    Science Advances: Supplementing HIV-ART with cannabinoids increases serotonin, BHB, and Ahr signaling while reducing secondary bile acids and acylcholines

    Authors: Lakmini S. Premadasa, Luis Romero, and Mahesh Mohan.

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