Will Pope Francis imitate Pope Innocent VIII?

Marijuana use is considered taboo by the Catholic Church. With this the Catholic pope holds a decisive power to influence marijuana laws and legalization efforts throughout the world. Pope Francis and his predecessors have employed this power since December 5, 1484, when Pope Innocent VIII (1432 – 1492) declared marijuana to be an unholy sacrament in a papal bull called the Summis desiderantes, meaning “desiring with supreme ardor.”

Unlike wine, cannabis in 1484 was regarded as a sacrament of a satanic mass because it was tied to witches who among other things were condemned by the Church for employing medicinal and hallucinogenic herbs—thought affecting chemicals—for healing purposes. Alleged witches were also being scapegoated for an extreme European and North American weather event known as The Little Ice Age that caused crop failures, famine, and increased crime. The harsh climate change made the public crazier than usual. By being linked to witches, cannabis connoisseurs were also seen as guilty of causing bad weather.

Innocent VIII was pope during the reign of Queen Isabella and King Ferdinand of Spain. The two monarchs were preoccupied with the Reconquista that reclaimed the Iberian peninsula from Muslim rule. Part of the strategy for domestic warfare against alleged internal enemies of the Spanish Empire was the formation of the Spanish Inquisition on November 1, 1478, in which Jews and Muslims were targeted if they didn’t immediately leave Spain or convert to Catholicism. Of those who didn’t, or who merely pretended to convert, over 275,000 Muslims were expelled. Many died as a result of their deportations. Of the luminaries to emerge was the infamous Castilian Grand Inquisitor Tomás de Torquemada (1420 – 1498) who tortured and burned women herbalists along with roughly two-thousand Jews and other heretics, including those caught using cannabis.

Thanks to the inebriated influences of Catholicism, England had largely suppressed medicinal cannabis use by the 1890s. Great Britain and the United States inherited the radical views held by many modern prohibitionists who conflate marijuana’s effects with opium or alcohol. Part of the problem originated in British-controlled India from an 1891 report on the effects of ganja on mentally ill patients. The review made ganja look worse than opium. False rumors of marijuana’s supposed ill-effects were linked to British imperialists by politicians who opposed the British opium trade in China. The opium wars produced the Boxer Rebellion; all of which culminated with the production of the 1972 movie classic Kung Fu in which Kwai Chang Caine, a Chinese Boxer, adds a mysterious herbal powder to his glass of water before confronting a drunk in a bar room scene.

Even stranger than drug history is a lasting obsession over prohibiting a simple beneficial plant. Religions and governments still wield cannabinoid illegality as a political or social weapon to be used as needed against certain types of people or different cultures. The problem in the U.S. for organized religion is marijuana’s prohibition cannot be based solely on a particular group’s religious beliefs. Arrests, detentions, and fines for marijuana consumption are legally justifiable only if marijuana can be scientifically proven to pose an actual physical threat to all people everywhere, not just some ideological threat to a culture still living in the Dark Ages.

Modern science isn’t buying it. As new research data emerges from all over the globe, cannabis and its components are receiving an ever expanding and exceptionally clean bill of health, particularly when compared to alcohol, opioids and other pharmaceutical drugs. Weed won’t kill anyone. The only excuse remaining for marijuana prohibition appears to be a religious one. A religious justification alone such as a taboo would make marijuana’s continued federal prohibition in the United States an unconstitutional establishment of religion under the First Amendment.

As Pope Francis continues his recovery from bilateral pneumonia, he might want to consider marijuana’s apparent ability to suppress or alter lung infections like COVID-19 as possibly indicative of marijuana’s overall medical potential. This is the second close call the pontiff has had with pneumonia. His first happened at age 23 when he ended up having part of a lung removed. Francis is pro-science in ways unlike any of his predecessors because he actually studied it. He could do himself and science discovery a monumental favor by issuing a papal bull that revokes Catholicism’s medieval rejection of medical and recreational cannabis. A drug peace is possible. The papal legalization of marijuana would also be a fitting finale to the Spanish Inquisition.

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3 Responses to Will Pope Francis imitate Pope Innocent VIII?

  1. Servetus says:

    Video story of FBI Director who was set up and busted by crooked cops for cocaine possession:

    FBI Director busted

  2. Servetus says:

    CBD proves effective in tissue repair for treating inflammation involving dental treatments:

    18-Mar-2025 — In vitro tests indicate that cannabidiol can stimulate the biomineralization of teeth even under inflammatory conditions, thus promoting tissue repair. […]

    In the experiment, cells from the dental pulp of mice were exposed to a cytokine called tumor necrosis factor alpha (TNF-α), which is involved in various inflammatory and autoimmune processes. They were then treated with different concentrations of cannabidiol for periods ranging from 24 hours to seven days.

    “The ability of the cells to survive and function in this environment was evaluated, which allowed us to determine if the substance has any bioactive effect on them,” […]

    The results showed that treatment with cannabidiol was able to inhibit the synthesis of inflammatory mediators, suggesting an anti-inflammatory effect, especially after 24 hours. In addition, the substance stimulated the capacity for tooth biomineralization.

    “These findings indicate that cannabidiol may be a promising bioactive substance for tissue repair in inflammatory contexts, which opens up new perspectives for its use in dental treatments, especially in regenerative dentistry, benefiting patients in different clinical situations,” says Paula-Silva. […]

    AAAS Public Science News Release: Study shows that cannabidiol may be a promising agent for promoting dental biomineralization. Researchers tested different concentrations of the substance on dental pulp cells. Results show promise for dental tissue repair

    Journal of Dentistry: Effects of cannabidiol on biomineralization and inflammatory mediators expression in immortalized murine dental pulp cells and macrophages under pro-inflammatory conditions

    Authors: Larissa Sthefani Sales, Alice Correa Silva-Sousa, Glauce Crivelaro Nascimento, Elaine Del Bel, Francisco Wanderley Garcia Paula-Silva.

  3. Servetus says:

    Inhibiting the cannabinoid receptor 1 (CB1R) protects the gut barrier involving alcohol binge drinking that leads to a condition called the “leaky gut.”

    19-Mar-2025–Heavy alcohol consumption is a leading cause of gastrointestinal diseases, with binge drinking linked to increased intestinal permeability—a condition commonly known as “leaky gut.” Despite the significant health impact of alcohol-associated gastrointestinal disorders, effective pharmacological treatments remain limited. A new study published in eGastroenterology explores the role of gut cannabinoid receptor 1 (CB1R) in alcohol binge-induced intestinal permeability and reveals how its inhibition can help protect the gut barrier. […]

    …alcohol bingeing increases endocannabinoid levels in the proximal small intestine, triggering CB1R activation in intestinal epithelial cells. This activation disrupts tight junction proteins, which generally maintain the integrity of the gut lining, leading to increased intestinal permeability. This process can allow harmful substances, such as bacteria and toxins, to enter the bloodstream, contributing to inflammation and other health complications.

    To investigate the role of CB1R, the researchers developed genetically modified mice with intestinal epithelial-specific CB1R deletion (CB1IEC−/− mice). They found that alcohol bingeing significantly increased gut permeability in normal mice, but this effect was absent in CB1IEC−/− mice, indicating that CB1R is a key mediator of alcohol-induced leaky gut. […]

    Additionally, the study examined the effects of pharmacological CB1R inhibition using a peripherally restricted CB1R antagonist (S)-MRI-1891. When administered to normal mice before alcohol bingeing, this compound successfully prevented the increase in intestinal permeability. However, the drug had no effect in CB1IEC−/− mice, further confirming that CB1R in the intestinal epithelium is responsible for alcohol-induced gut barrier disruption.

    Mechanistic studies revealed that CB1R activation in the gut epithelium triggers the ERK1/2 signalling pathway, which leads to the downregulation of tight junction proteins and a reduction in villus length—key factors contributing to a leaky gut. By inhibiting CB1R, researchers could reverse these changes, restoring gut barrier function and improving overall gut health.

    These findings hold significant implications for the treatment of alcohol-related digestive disorders. Currently, there are no FDA-approved drugs specifically designed to treat alcohol-induced intestinal permeability. The study suggests that targeting CB1R with peripherally restricted antagonists could provide a novel therapeutic approach, potentially preventing systemic inflammation and other complications associated with alcohol-induced gut barrier dysfunction. […]

    AAAS Public Science News Release: Blocking gut cannabinoids may prevent leaky gut

    eGastroenterology: Gut cannabinoid receptor 1 regulates alcohol binge-induced intestinal permeability

    Authors: Luca Maccioni1, Szabolcs Dvorácskó, Grzegorz Godlewski, Malliga R. Bin Gaol, George Kunos.

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