Marijuana and the American drug rehab industry

American drug treatment programs specializing in cannabis use disorder (CUD) achieve long term marijuana abstinence rates of only 14-to-22 percent. Opioid addictions treated using buprenorphine have a 90 percent abstinence rate over two-to-five years. The differences in treatment success highlight the fact that alleged marijuana addictions are radically different from opioid addictions.

One source of confusion is that CUD is defined by psychologists and psychiatrists rather than medical doctors or neuroscientists. For example, neuroscientists have identified addiction pathways in the brain for cocaine and opioids as well as nicotine, but no neural addiction pathways have been identified for cannabis. Medical science has moved on. Opioid addictions are now viewed as an illness comparable to a disease like diabetes.

Despite a lack of biological evidence for marijuana dependency, mental health professionals cite data hinged on adolescent users and a vague social definition of a CUD:

An estimated 9 to 30% of cannabis users become dependent on cannabis and an estimated one in six adolescent cannabis users has cannabis use disorder. People who start using cannabis before age 18 are four to seven times more likely to develop a cannabis use disorder than people who begin as adults, according to NIDA. Withdrawal symptoms can include irritability, changes in appetite, depression, and twitches and shakes.

To explain all the twitching and shaking, most psychologists and psychiatrists rely upon a self-serving definition of CUD found in the official Diagnostic and Statistical Manual of Mental Disorders, also known as DSM-5-TR. According to the manual, CUD is a “problematic pattern of cannabis use” leading to “clinically significant” impairment or distress, as characterized by at least two or more criteria occurring within a 12-month period: cannabis is often taken in larger amounts or over a longer period than intended; there exist persistent desires or unsuccessful efforts to cut down or control use; a great deal of time is spent obtaining, using, or recovering from cannabis; a strong urge persists to use cannabis; a failure to fulfill major obligations at work, school, or home due to use; continued use despite social or interpersonal problems caused by cannabis; giving up or reducing important activities because of use; use in physically hazardous situations; continued use despite physical or psychological problems caused or worsened by cannabis; tolerance or needing more cannabis to achieve the same effect; and withdrawal symptoms, or using cannabis to relieve withdrawal.

A heroin addict’s abrupt withdrawal or detox from heroin can involve many hours of vomiting up nearly everything the individual has eaten for the past three days. Ceasing heavy marijuana use does not typically create withdrawal symptoms. If someone’s cannabis supply is cut off after it’s been used medicinally for treating conditions such as anxiety disorders or major depression, then these disease symptoms are likely to reoccur, but this does not make chronic medicinal use an addiction. This idea has led some marijuana consumers to suggest that much of the wonder weed’s recreational use is actually medical use.

Marijuana-focused drug treatment programs have traditionally employed therapies such as Cognitive Behavioral Therapy (CBT) that helps users identify triggers to cannabis use. Motivational Enhancement Therapy (MET) focuses on building motivation, and Contingency Management (CT) uses rewards for meeting goals. Holistic and Supportive Approaches include mindfulness, exercise and nutritional counseling to create a sense of wellbeing. Marijuana Anonymous is the cannabis equivalent of Alcoholics Anonymous and focuses on accountability and community, said to be critical for a sustained recovery.

Pharmaceutical drug treatments for marijuana addictions involve non-FDA-approved experimental options. These include Dronabinol and Nabiximols for withdrawal symptoms, and N-acetylcysteine and gabapentin that give mixed results. None of these drugs or supplements are recommended. Dronabinol is the international non-proprietary name in a pharmaceutical context for THC.

Clinical significance widens the field since the most clinically significant social impairments that can occur with marijuana include being arrested for possession and sentenced to jail, or getting fired from one’s job because of a positive urine test. The legal connection was once a big cash cow for the marijuana rehab industry. In some parts of the US, in a legal process called diversion, a court would sentence a person convicted of marijuana possession to a rehab program with the stipulation that upon completion of the official brainwashing curriculum their criminal charges would be dropped. The anti-marijuana brainwashing effort has had little effect. As more state residents continue to opt for legalization the marijuana rehab business is falling on hard times. Aside from psychologists, psychiatrists, and politicians, it’s difficult to find a cannabis consumer or anyone else who believes marijuana is addictive.

Many elected public officials and employees of the federal government still describe marijuana as addictive. A failure by a president or a member of Congress to support marijuana prohibition along with its mythologies would mean drug rehabs and other businesses profiting from marijuana drug enforcement would lose their ability to donate money to helpful politicians to aid their re-election campaigns.

On the business side, transformations of the pharmaceutical industry are inevitable. If a specific cannabinoid or its chemical analog succeeds in replacing opioids as a non-toxic addiction-free pain reliever then certain pharmaceutical companies will suffer big losses in the global opioid market, estimated for 2025 to be $24.8 billion in total revenue. Pushback from businesses with a financial interest in promoting cannabis prohibition can be expected.

Despite a few new adjustments for the pharmaceutical industries, a freed marijuana marketplace will be good news for the economy and for democracies in general. Employment opportunities will improve, and not just for the marijuana industry. The government and its contractors will finally be allowed to hire marijuana consumers of all types who seek government jobs, including jobs that require a security clearance. The result will be the displacement of large numbers of professionally unqualified religious conservatives and true believers who owe their social and discriminatory employment status to puritanical rejections of marijuana and democracy. The current quest by organizations such as the New Apostolic Reformation to construct a new theocracy at the federal level and all other levels could be derailed. With so much to gain from cannabis legalization and so much to lose the stakes remain high.

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6 Responses to Marijuana and the American drug rehab industry

  1. Shane from Slidell says:

    Looks like Glenn Greenwald is also starting to turn on Trump:
    https://rumble.com/v6wxwmq-stephen-millers-blatant-lies-debunked.html
    I don’t know who lies more, him, RFK Jr., Obama, Greg Gutfeld, Liz Murrill, or Jeff Landry?

  2. Servetus says:

    Women who use cannabis instead of alcohol are 50% less likely to experience an unplanned pregnancy:

    31-Jul-2025 — A new study has found that, among women with a high desire to avoid becoming pregnant, those who drank heavily had a 50% higher risk of becoming pregnant than those who drank moderately or not at all. In contrast, participants who used cannabis were no more likely to have an undesired pregnancy than participants who did not use cannabis.

    From a larger sample of over 2,000 non-pregnant women aged 15-34, researchers identified a subgroup of 936 who didn’t want to get pregnant. Within that subgroup, 429 reported heavy drinking (as measured using a standard alcohol screening questionnaire) and 362 reported using cannabis (including 157 who reported daily or almost daily use).

    Those who drank heavily and those who used cannabis frequently had a higher overall desire to avoid pregnancy, compared with participants who drank moderately or not at all and participants who did not use cannabis. […]

    Lead author Dr Sarah Raifman, of the University of California, San Francisco, School of Medicine, comments: “This study made two important findings. First, non-pregnant women who drink heavily appear, on average, to have a higher desire to avoid pregnancy than those who drink moderately or not at all. Second, drinking heavily as opposed to moderately or not at all appears to put those who most want to avoid pregnancy at higher risk of becoming pregnant within one year. Finding out why those pregnancies happen is the next step in our research.”

    “In the meantime, given the potentially life-altering effects of fetal alcohol spectrum disorders (which occur when a fetus is exposed to alcohol through the mother’s drinking) and the fact that the risk of FASD increases with the amount and duration of the mother’s drinking, it’s important for doctors and clinicians to support women who drink heavily to stop drinking as soon as they suspect an unintentional pregnancy.” […]

    AAAS Public Science News Release: Heavy drinking raises the risk of undesired pregnancy; cannabis use does not

    Addiction: Alcohol and drug use and attainment of pregnancy preferences in the southwestern United States: A longitudinal cohort study

    Authors: Sarah Raifman, Sarah C. M. Roberts, Corinne H. Rocca

  3. Servetus says:

    Fermented fruit resulted in humans developing the genes to quickly metabolize alcohol:

    31-Jul-2025 — New research from the University of St Andrews and Dartmouth College examines the crucial, but until now, overlooked, role of ‘scrumped’ fruit in the lives of great apes and the origins of human feasting.

    Published today (Thursday 31 July) in BioScience, this pioneering study is the first to tackle the mystery of why humans are so astoundingly good at metabolising alcohol.

    The findings show that feeding on fermented fruits gathered from the forest floor is an important behaviour in the lives of African apes, and one that explains why they, and we, evolved the ability to digest alcohol efficiently. […]

    Co-author Nathaniel Dominy, the Charles Hansen Professor of Anthropology at Dartmouth College, said: “One problem for the researchers was that there was no word to describe ‘feeding on fruits gathered from the forest floor.’ Nobody wants more jargon, but without a word to talk about something, a behaviour is easily overlooked”

    They repurposed the word ‘scrumping’, the act of gathering, or sometimes stealing, windfallen apples and other fruit. It is an English derivation of the middle low German word schrimpen, a mediaeval noun for describing overripe or fermented fruit. […]

    A range of work points towards the fact that ripe fruit contain small-but scrumptious-levels of ethanol, there have been recent findings hinting at the importance of chimpanzees’ feeding socially on fruits.

    Building on those findings, this paper has revealed that, counter to widespread beliefs that primates do not ‘scrump,’ African apes, but not orangutans, ‘scrump’ on a regular basis. This behavioural difference is crucial, as the same pattern is reflected in an important genetic mutation that allows African apes to metabolise alcohol 40x more efficiently than orangutans and other primates, and could be an important link to the evolution of humans’ long-standing affair with alcohol. […]

    AAAS Public Science News Release: Scrumped fruit key to chimpanzee life and a major force of human evolution

    Bioscience–A Forum for Integrating the Life Sciences: Fermented fruits: scrumping, sharing, and the origin of feasting

    Authors: Nathaniel J Dominy , Luke D Fannin , Erin R Vogel , Martha M Robbins , Catherine Hobaiter.

  4. Servetus says:

    Psychedelics promotes new connections in the brain:

    4-Aug-2025 — Understanding exactly how psychedelics promote new connections in the brain is critical to developing targeted, non-hallucinogenic therapeutics that can treat neurodegenerative and neuropsychiatric diseases. To achieve this, researchers are mapping the biochemical pathways involved in both neuroplasticity and hallucinations.

    In new research led by the University of California, Davis, researchers found that non-hallucinogenic versions of psychedelic drugs promote neuroplasticity through the same biochemical pathway as psychedelics. However, unlike psychedelics, they don’t activate genes long thought to be key players in that process.

    The research…compared the biochemical pathways activated by the hallucinogenic compound 5-MeO-DMT and its non-hallucinogenic analog tabernanthalog (TBG). […]

    “The prevailing hypothesis in the field was that psychedelics promote neuroplasticity by causing this big burst of glutamate in the brain, which then turns on intermediate early genes,” said David E. Olson, director of the Institute for Psychedelics and Neurotherapeutics and a professor of chemistry and of biochemistry and molecular medicine at UC Davis. “We now know that non-hallucinogenic compounds like TBG can promote neuroplasticity without inducing a glutamate burst or immediate early gene activation.” […]

    The team found that TBG promotes neuroplasticity by activating the same psychedelic receptor as 5-MeO-DMT, but the difference is the extent of the activation.

    The researchers also provide the first direct evidence that a non-hallucinogenic psychedelic analog like TBG, produces sustained antidepressant–like effects through the growth of dendritic spines in the brain’s prefrontal cortex. […]

    AAAS Public Science News Release: Psychedelics and non-hallucinogenic analogs work through the same receptor, up to a point

    Nature Neuroscience: The psychoplastogen tabernanthalog induces neuroplasticity without proximate immediate early gene activation

    Authors: Isak K. Aarrestad, Lindsay P. Cameron, Ethan M. Fenton, Austen B. Casey, Daniel R. Rijsketic, Seona D. Patel, Rohini Sambyal, Shane B. Johnson, Calvin Ly, Jayashri Viswanathan, Eden V. Barragan, Stephanie A. Lozano, Nicolas Seban, Hongru Hu, Noel A. Powell, Milan Chytil, Retsina Meyer, David Rose, Chris Hempel, Eric Olson, Hanne D. Hansen, Clara A. Madsen, Gitte M. Knudsen, Chase Redd, Damian G. Wheeler, Nathaniel Guanzon, Jessie Muir, Joseph J. Hennessey, Gerald Quon, John D. McCorvy, Sunil P. Gandhi, Kurt Rasmussen, Conor Liston, John A. Gray, Boris D. Heifets, Alex S. Nord, Christina K. Kim & David E. Olson.

  5. Servetus says:

    UC Irvine researchers find that a form of vitamin B3 and a green tea anti-oxidant can reverse age related deficits such as amyloid proteins in the brain, a symptom of Alzheimer’s disease:

    6-Aug-2025 – In a paper published recently in the journal GeroScience … a combination of naturally occurring compounds – nicotinamide (a form of vitamin B3) and epigallocatechin gallate (a green tea antioxidant) – can reinstate levels of guanosine triphosphate, an essential energy molecule in brain cells. In tests on neurons in a dish, the treatment reversed age-related cellular deficits and improved the brain cells’ ability to clear damaging amyloid protein aggregates, an Alzheimer’s hallmark.

    “As people age, their brains show a decline in neuronal energy levels, which limits the ability to remove unwanted proteins and damaged components,” said lead author Gregory Brewer, adjunct professor of biomedical engineering at UC Irvine. “We found that restoring energy levels helps neurons regain this critical cleanup function.”

    The researchers used a genetically encoded fluorescent sensor called GEVAL to track live guanosine triphosphate levels in neurons from aged Alzheimer’s model mice. They discovered that free GTP levels declined with age – particularly in mitochondria, the cells’ energy hubs – leading to impaired autophagy, the process by which cells eliminate damaged components.

    But when aged neurons were treated for just 24 hours with nicotinamide and epigallocatechin gallate, GTP levels were restored to those typically seen in younger cells. This revival triggered a cascade of benefits: improved energy metabolism; activation of key GTPases involved in cellular trafficking, Rab7 and Arl8b; and efficient clearance of amyloid beta aggregates. Oxidative stress, another contributor to neurodegeneration, was also reduced.

    “This study highlights GTP as a previously underappreciated energy source driving vital brain functions,” Brewer said. “By supplementing the brain’s energy systems with compounds that are already available as dietary supplements, we may have a new path toward treating age-related cognitive decline and Alzheimer’s disease.”

    He cautioned, “More work is going to be required to find the best way to administer this treatment, since a recent clinical trial involving UC Irvine researchers showed that oral nicotinamide was not very effective because of inactivation in the bloodstream.” […]

    AAAS Public Science News Release: UC Irvine researchers find combination of natural compounds for brain cleaning — Treatment removes harmful protein buildup associated with Alzheimer’s disease

    GeroScience: Treatment of age-related decreases in GTP levels restores endocytosis and autophagy

    Authors: R. A. Santana, J. M. McWhirt & G. J. Brewer

  6. Servetus says:

    What if your dog ingests cocaine? Protect pets from future accidents:

    17-AUG-2025–Dr Jake Johnson is a cardiology resident at North Carolina State University’s College of Veterinary Medicine where he focuses on bridging the gap between advanced cardiac knowledge and practical clinical application. He is the first author of a new Frontiers in Veterinary Science article that describes a rare case study of the treatment of a lethargic and unresponsive chihuahua who visited the vet’s for treatment. […]

    Dr Jake Johnson is a cardiology resident at North Carolina State University’s College of Veterinary Medicine where he focuses on bridging the gap between advanced cardiac knowledge and practical clinical application. He is the first author of a new Frontiers in Veterinary Science article that describes a rare case study of the treatment of a lethargic and unresponsive chihuahua who visited the vet’s for treatment. We talked to Johnson about his career and a particular four-legged patient that ingested cocaine. […]

    Which symptoms did the chihuahua – the patient in the current study –present with, and how did you arrive at the diagnosis?

    The dog initially arrived at the referring clinic with collapsing episodes and an abnormally low heart rate. Given previous suspected illicit substance ingestion, a point of care urine drug screen was performed which was positive for cocaine, this was later verified during another send-out test. […]

    What steps can owners take to prevent their pets from accidentally ingesting such substances?

    Dogs are natural scavengers and will investigate anything on the ground, so be vigilant during walks. Pet owners can prevent ingestion by keeping their dog on a leash, watching for any attempts to pick up or consume unknown items from the ground, and using a basket muzzle if necessary. Train your dog with ‘leave it’ and ‘drop it’ commands, which can be lifesaving if they encounter dangerous substances. If you suspect any exposure or feel as though your dog is not acting normally, it’s important to seek immediate veterinary attention – early intervention can be lifesaving. […]

    In your opinion, why is your research important?

    Case reports are crucial in veterinary medicine by providing real-world examples. They capture clinical scenarios that larger studies might miss, preserve unusual presentations for future reference, and help build our collective understanding of rare presentations, ultimately improving emergency preparedness and treatment protocols. […]

    Frontiers-Science News: What do you do if your dog ingests cocaine? How one researcher is trying to protect pets from future accidents

    Frontiers–Veterinary Pharmacology and Toxicology: Cocaine induced first-degree and high-grade second-degree atrioventricular block in a dog: a case report

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