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John Prine, RIP

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31 comments to John Prine, RIP

  • DdC

    Requiescat In Pace John & Charlotte

    I started a thread when he was hospitalized. Couple days later his wife said he was on ventilation but stable. RIP John…

    March 29, 2020
    John Prine in Critical Condition
    After Coronavirus-Related Hospitalization

    Looks like it got another one… RIP Charlotte

    Charlotte Figi, namesake of Charlotte’s Web
    medical marijuana strain, dies with COVID-19
    Colo. (KRDO) — Charlotte Figi, the little girl who inspired the low-THC medical marijuana strain, “Charlotte’s Web,” has passed away with COVID-19.

  • Sam

    Sweet songs never last too long.

  • Servetus

    Coronavirus Vaccine: Where Are We and What’s Next?

    https://www.youtube.com/watch?v=gDY8pH6OWBc

  • It’s going to be finish of mine day, except before finish I am reading this
    enormous paragraph to improve my experience.

  • Democracy is rule by the poor

    OT

    Die for the Dow? Rush to join the Fox News/evangelical body count?
    Right-wing authoritarians say “what the fuck you waiting for?

    Now that authoritarian followers are taking to the streets to protest is a perfect time to re-read Bob Altemeyer’s free online book “The Authoritarians.” It’s helpful to understand that the people protecting the “King,” are not interested in democracy.

    Right-wing authoritarian followers will willingly spread disease to protect their leader.

    Kevin Sabet is spewing nonsense in today’s New York Post.

    • DdC

      Authoritarians discovered after 12,000 years of Ganja use. Prohibitions brought anxiety and fear, inflamed amygdala, begetting protection, provided for unquestioning loyalty. Empathy is the first casulty.

      Clinical Endocannabinoid Deficiency

      Endocannabinoid System 101
      the most important body system that you’ve never heard of.

      Constant propaganda tweaking or tweeting the dirty masses. Followers Tempting their own god and something about thou shalt not kill innocent elderly you passed it to, being selfish and weak. Cowardice among politicians putting illogical acts before citizens lives. War Zone hospitals bartering for PPE. Who else but Putin could prosper from this.

      “All propaganda must be so popular and on such an intellectual level, that even the most stupid of those towards whom it is directed will understand it. Therefore, the intellectual level of the propaganda must be lower the larger the number of people who are to be influenced by it.”

      “Through clever and constant application of propaganda, people can be made to see paradise as hell, and also the other way around, to consider the most wretched sort of life as paradise.”
      ~ From Benito Mussolini,
      London Sunday Express,
      December 8, 1935

      Ganja sets you free, and that seems to be harder than blind obedience. Thinking about things. Peaceful Pacifists hunkering down, gun nuts spreading it among themselves. If I was invading, that’s how I’d do. Avoiding the problem is cutting Seniors and Special Needs Social Security, one way or another. So close.

      Marijuana use among older Americans up 75% in 4 years

      Trump’s Chumps protesting socialist distancing, spherical earths and basic reality. Science Sucks Rush’s Ditto’s clutching bible verses to spew at alt christian Covidiots. Food Banks over run, bail out the air lines not flying anyone. Constitutional rights to not have contagious lemmings do harm to Americans. Jim Jones or Falwell Cults suicide packs are not a right covered by the BoR. MSM as quiet as a mouse about solutions getting in the way of blaming someone.…

      I’m not seeing much change since I semi-retired, Groceries and Ganja delivered, paid by TLRY & GWPH. Old flicks and tunes, arts and crafts weaving dream catchers out of hemp. Online about the same, less tv non news speculations, perceptions and presumptions, like they do about Ganja.

      Cannabis Industry Is America’s Fastest-Growing Sector, 15% growth in 2019 Employs Over 240,000 Full-Time Workers

      U.S. Federal Cannabis Legalization
      Could Be Worth $128.8 Billion in Taxes
      and 1.6 Million Jobs

      Authoritarians and the Drug War was the red flag jerking 50 years with bipartisan saluting, shunning and stigmatizing. Sabeteurs stealing taxes from Cv19 victms to lie and keep Ganja schedule#1, banned from research. ¯\_(ツ)_/¯

  • NorCalNative

    Up in Humboldt County behind the Redwood Curtain, weed is an all-cash business and delivery services have shut down.

    We have 52 COVID-19 positives, 3 Hospital admissions and zero deaths. These numbers make the economic hardships look excessive to many and the shutdown anger is growing.

    A local website had a phone video of Arcata police tasering a shirtless agitated man. At one point, with 4 cops on top of him you can hear him say “Everything is so beautiful, so purple, so bright.”

  • Tweeking'ForJesus

    “This all could have been prevented if he had simply followed the guidelines and kept his shirt on while tweeking!”

    https://kymkemp.com/2020/04/17/on-wednesday-arcata-police-tasered-and-subdued-agitated-man-video/

  • ImpossibleHeSaid

    This just in: Israel’s Prime Minister Benjamin Netanyahu and his rival Benny Gantz have agreed to form a unity government. Anybody who’s been following this will know that Israel will now legalize recreational cannabis, which is a key position of Benny Gantz.

    https://www.wsj.com/articles/israeli-prime-minister-netanyahu-and-rival-benny-gantz-agree-to-form-unity-government-11587401728

  • Green Leb

    “Parliament’s decision was really driven by economic motives, nothing else.”
    Alain Aoun, a senior MP in the Free Patriotic Movement founded by President Michel Aoun.

    https://preview.tinyurl.com/DoshNeedDosh

  • Servetus

    More evidence that schizophrenia is caused by genetic changes, and not by inhaling marijuana as prohibitionists often assert:

    21-APR-2020 – a genetic change increases the risk of developing schizophrenia and highlights new opportunities for drug treatment say researchers. […]

    In the human genome, small sections of DNA have been found to be duplicated (copied) or deleted in a small number of people, a phenomenon known as Copy Number Variation. Some of these genetic changes are linked to an increased risk of developing neurodevelopmental disorders, such as schizophrenia and autism, but the disease mechanisms involved remain largely unknown. For example, people with a DNA duplication at chromosome 16p11.2, that results in having extra copies of around 30 different genes, are approximately 15 times more likely to develop schizophrenia than people without the duplication. Why this should be the case is very poorly understood.

    For the first time, research reported by the team in the journal Cell Reports, has shown that the 16p11.2 duplication impacts on a number of different inhibitory neuron types, neurons that use the neurotransmitter GABA, in brain areas dysfunctional in schizophrenia. These brain areas include the prefrontal cortex, hippocampus and amygdala. The researchers also show that these GABA neuron changes are accompanied by impaired functional communication between the same brain regions. Importantly, the researchers found that 16p11.2 duplication also results in cognitive and social deficits. These deficits not only parallel those seen in patients with schizophrenia, but are also known to involve the brain regions identified as being dysfunctional as a result of 16p11.2 duplication.

    Dr Neil Dawson, the lead researcher from Lancaster University said: “Our data give new insight into how 16p11.2 duplication increases the risk of developing schizophrenia and the mechanisms involved. A key finding is the observation of disrupted connectivity between brain regions that are known to be dysfunctional in schizophrenia. We can now test the ability of drugs to restore these changes as part of ongoing research to develop better treatments for the disorder”. […]

    AAAS Public News Release: New insight into how a genetic change increases the risk of schizophrenia

  • Servetus

    A mouse study reveals how their brain responds to binge drinking:

    4-17-2020 — A key brain region for controlling binge drinking has been found. The unique intersection in the brain between the stress system and binge drinking may be the key to controlling the urge to binge drink, report Medical University of South Carolina researchers.

    A team of National Institutes of Health-funded researchers at the Medical University of South Carolina has found that deactivating a stress-signaling system in a brain area known for motivation and emotion-related behaviors decreases binge drinking. The study, which was published online in February and is to appear in the May issue of Neuropharmacology, pinpoints a particular system in a specific brain region that can be manipulated to reduce harmful binge drinking. […]

    But how much alcohol must be consumed to qualify a drinking session as a binge?

    A binge, as defined by the National Institute on Alcohol Abuse and Alcoholism, or NIAAA, means drinking to the legal limit of intoxication within two hours. Becker put this into perspective.

    “This is four standard drinks for a woman or five drinks for a male – consumed over about a two-hour period,” he explained.
    JR Haun, a graduate student in the Becker laboratory and first author on the article, described what the NIAAA considers ‘standard’ related to certain beverage types.

    “A drink is defined as roughly one 12-ounce can of beer, a five-ounce glass of wine or a standard 1.5 ounce shot of distilled spirits,” he explained, adding that the serving sizes can vary based on the percentage of pure alcohol in the drink. […]

    Notorious narcotic drugs of abuse, such as morphine, heroin and oxycontin/oxycodone act on the opioid-receptor system, producing the pleasurable effects that make these drugs so addictive.

    However, there is an odd opioid receptor out, so to speak, that is not involved in signaling pleasure.

    “The kappa opioid-receptor system is the antithesis to other opioid receptors,” explained Haun. “It’s often referred to as an anti-reward system.”

    Instead of feelings of pleasure, the kappa opioid receptor produces stress and discontent.

    When people drink and experience positive effects, that is partially due to pleasurable opioid receptors being activated. However, after they have finished drinking and nausea, headache, and the stress of withdrawal start to set in, the kappa opioid receptor system has been activated.

    Becker’s team found that turning off the kappa opioid receptors in the brain decreased binge drinking. This finding suggests that the kappa opioid receptor system is important not only in the negative state of withdrawal but also in driving binge drinking itself. […]

    Blocking kappa opioid receptors in the extended amygdala, therefore, could act as a therapy to taper binge drinking.
    So will there soon be a pill to curb the urge to binge?
    According to Becker, if such a therapy were developed, he believes it would be best tailored for those who have difficulty controlling more chronic heavy drinking, such as those with an alcohol use disorder.

    AAAS Public News Release: A key brain region for controlling binge drinking has been found–
    The unique intersection in the brain between the stress system and binge drinking may be the key to controlling the urge to binge drink, report Medical University of South Carolina researchers

    Original article: http://dx.doi.org/10.1016/j.neuropharm.2020.107984

  • Servetus

    Mandatory testing of marijuana in California for contaminants is taking a bite out of production and profits:

    Abstract

    Most U.S. states that have regulated and taxed cannabis have imposed some form of mandatory safety testing requirements. In California, the country’s largest and oldest legal cannabis market, mandatory testing was first enforced by state regulators in July 2018, and additional mandatory tests were introduced at the end of 2018. All cannabis must be tested and labeled as certified by a state-licensed cannabis testing laboratory before it can be legally marketed in California. Every batch that is sold by licensed retailers must be tested for more than 100 contaminants, including 66 pesticides with tolerance levels lower than the levels allowable for any other agricultural product in California. This paper estimates the costs of compliance with mandatory cannabis testing laws and regulations, using California’s testing regime as a case study. We use state government data, data collected from testing laboratories, and data collected from lab equipment suppliers to run a set of Monte Carlo simulations and estimate the cost per pound of compliance with California’s new cannabis testing regulations. We find that cost per pound is highly sensitive to average batch size and testing failure rates. We present results under a variety of different assumptions about batch size and failure rates. We also find that under realistic assumptions, the loss of cannabis that must be destroyed if a batch fails testing accounts for a larger share of total testing costs than does the cost of the lab tests. Using our best estimates of average batch size (8 pounds) and failure rate (4%) in the 2019 California market, we estimate testing cost at $136 per pound of dried cannabis flower, or about 10 percent of the reported average wholesale price of legal cannabis in the state. Our findings explain effects of the testing standards on the cost of supplying legal licensed cannabis, in California, other U.S. states, and foreign jurisdictions with similar testing regimes.

    Publication: Valdes-Donoso P, Sumner DA, Goldstein R (2020) Costs of cannabis testing compliance: Assessing mandatory testing in the California cannabis market. PLoS ONE 15(4): e0232041. https://doi.org/10.1371/journal.pone.0232041

  • D.A.R.E in the headlights

    Hope you all saw this…..

    ‘Less than two years before this cop was arrested for running a child porn ring, Officer Kovacs received the “Law Enforcement Officer of the Year” Award. When presented with the honor, the Beavercreek police department praised him for his work with young children.’

    https://masscentral.com/highly-decorated-d-a-r-e-cop-arrested-for-running-an-enormous-child-porn-ring/

    • kaptinemo

      Long ago, back in the 2000’s, a cop came into the DrugSenseChat with the line “I’m a 14 year old girl with blonde hair and blue eyes.”

      It had to be a cop. No finesse. No manners. Just jumped right into what he no-doubt thought was a virtual den of dirty, disheveled, drug-addled pederasts feverishly rubbing hands together at the prospect of their next statutory rape. After all, they were ‘drug law reformers’ and thus had to be reprobates!

      Of course, no one took the bait. He repeated his line; we ignored him and just went on with our chat regarding legal tactics. He quickly got bored and left.

      Given this latest, it really makes you wonder.

  • Servetus

    Identifying male hemp seedlings for CBD production has benefited from an undergraduate-led project at Salisbury University:

    27-APR-2020 — The surge in cannabidiol (CBD) popularity means more farmers are growing non-intoxicating strains of cannabis, or hemp, for CBD production. This new market has led to commercial genetic tests for early determination of hemp plant sex. However, a new study has found that these tests may not all produce accurate results.

    CBD is used as an alternative treatment for pain and anxiety and various medical conditions. Unfertilized female cannabis plants produce high amounts of the CBD precursor in their flowers, making it important to identify and eliminate male plants at the seedling stage. […]

    “The results from our undergraduate-led project can help hemp growers make accurate sex determination of seedlings,” said Allison Nalesnik, senior undergraduate student at Salisbury University. “This could help increase the yield of CBD, which should reduce prices for the public.”

    Commercially available genetic tests use DNA markers known as primer pairs to identify male plants weeks before this could be determined visually. This helps farmers avoid spending time and money on growing plants that don’t produce flowers and that could potentially lower CBD production by fertilizing female plants. […]

    “Two of the primer pairs — SCAR119 and MADC2 — were effective for determining the sex of cannabis seedlings,” said Nalesnik. “The ineffective primer set would need to be tested further to more confidently say whether or not it is actually scientifically useful.”

    Next steps for this research include investigating DNA markers that are only found on the male chromosome to see if these offer a more efficient way to determine the sex of hemp seedlings.

    AAAS Public News Release: What’s the best way to identify male hemp seedlings? More accurate sex determination could increase yields and lower price of CBD

  • Servetus

    A brief history of medicine:

    I have an headache.
    2000 BCE: Here, smoke this flower.
    1000 CE: Here, say this prayer.
    1850 CE: Here, drink this potion.
    1930 CE: Here, swallow this pill.
    1950 CE: Here, take this antibiotic.
    2020 CE: Here, smoke this flower.

    (other renditions of this medical meme exist elsewhere)

  • NorCalNative

    Self medication as survival strategy. I spent much of the day yesterday reading the link DdC provided as well as many full studies used as references.

    Research has shown that THC and CBD decrease proinflammatory cytokines responsible for the “cytokine storm” that requires intubation and ventilation.

    This is immunosuppression cuz the immune system is creating the cytokine storm to combat the viral invader.

    Since most people are unable to get tested without showing symptoms it makes sense to fuel up your endocannabinoid system ASAP if you feel any of the known symptoms.

    It’s not clear to me that toking would be problematic. However, out of caution it’s probably better to seek out the big guns, i.e., full plant extracts. If you have a good CBD supplier like Charlotte’s Web that could be a good choice if you don’t have dispensary access.

    I’m certainly not against efficacious efforts by Big Pharma but access requires a physician and you might already be halfway dead before you can even present yourself for medical care. If you’re cannabis naive go with CBD. If you’re not, it still makes sense to have some CBD in the mix.

    Good luck and be safe out there.

    • DdC

      I used to check patients O2 with a finger monitor. Seems to be an indicator. I’ve posted about Hemp Oil helping a patient keep off of ABs, not for a virus but enhancing the immune to fuel the battle. If Ganja including all of the synergy of cannabinoids can boost the EDC to take care of whatever. Bringing it back to where it once belonged jojo. I’m assuming everybody else has it, so everybody I’m not sure of – back off.

      This sheltering seems so far, so good, knockonwood, to have less traffic as the only real difference. I’ve been practicing retirement a while, getting the hang of it. More deliveries and curbside? Still can’t figure out what toilet paper has to do with anything. Glad alls well, haven’t run into too many with personal experience. Can’t find anything on how many stoners are statistics or humm, not.

      50 years of prevention, no cold, no big pharma, flu shots or vax. Not opposed, just don’t go to doctors unless I can’t handle it. Last time I got food poisoning in Eureka about 20 years ago, they gave me a suppository. I ask why since I smoke pot regularly it didn’t stop the nausea? She didn’t know. I said I’ll make sure not to mix them up and got the ER to laugh. Be Well.

      Endocannabinoid System 101
      https://www.thorne.com/take-5-daily/article/endocannabinoid-system-101
      the most important body system that you’ve never heard of.

      Cannabis Synergy
      https://t.co/pYtNRTtwel?amp=1

      Synergy
      https://pbs.twimg.com/media/EXUIV8yVcAAfGc7?format=jpg&name=360×360

      Cv19
      https://pbs.twimg.com/media/EXUKDu3UMAAzfrg?format=jpg&name=360×360

      CBG
      https://pbs.twimg.com/media/EXYowe8U8AExEMI?format=jpg&name=360×360

      • darkcycle

        My doctor has said that a finger O2 Oximeter can be a very useful thing to have. The idea being you can keep track of your Blood O2 saturation in order to know if and when to present at the ER. Anything below 75% can be trouble, if you get to 60, you better already be at the door of the Hospital, because that is critically low. They’re inexpensive, I got mine for around 45 dollars and they’re available at your local Pharmacy or on line. Good investment in this day and age. Stay healthy.

  • Daniel Williams

    Pete posts a fitting tribute to one of our greatest troubadours, and in the span of 30 days receives 26 comments, 23 of which make no mention of John or his passing.

    Stoners take a lotta unwarranted grief about attention spans, but wtf?

    • darkcycle

      RIP John Prine. There, ya happy? He will be missed….much like occasional open threads for the sort of thing that is happening here. Stay well, Dan.

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